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Isoniazid- niacin related compound used to treat tuberculosis, found by Stratton et al to have powerful antichlamydial effect.

1st day of 7th Tini pulse: first one on INH

I thought I'd mark this startup of my first day on my 7th tinii pulse, and the first one I've taken having added INHi (currently at 150mg). I have no idea what difference being on INH will make, if any. Theoretically, one would think that it's increased potency for Cpni might drive more RB's into the cryptic phase than the other abxi I'm on, making for a bigger die-off reaction on the Tini.

I had about three days last weekend on the INH of feeling a surge of energy and mental ability, then during the week the endotoxini reactions (cold, fatigue, ache) came back. Today on the Tini I had some wave of aches, but feel a bit more energy buzz as I often do in the first hours of a pulse, before the toxin release gets too bad. At least I know that a Vitamin C flush on day 3 usually does the trick. I'll report in as this pulse continues. 

INH and Clearing Cpn from immune cells

Looking again at the patent materials and having an interest particularly in their discovery of INH as an antichlamydial agent I selected this excerpt because of it's importance in restoring immunei system functioning in those of us who have been immuno-compromised by Cpni. My daughter, for example, with terrible CFSi/FM, gets every virus which happens by and always gets a worse case of it. Prior to treatment, I also got colds frequently. Cpn infects macrophages and monocytes, rendering these infected immune cells less functional. If this is a predominant site of one's infection, then it stands to reason that your immune system sucks! Or, more accurately, is being sucked on... because Cpn functions parasitically by stealing the mitochondrial energy of the cells it infects.

I have highlighted and underlined some critical ideas in this excerpt. Thanks to Chuck Strattoni, et al for your brilliant and underappreciated discoveries:

The INH "Pink's"

Since I posted on the first couple days of herx from INH, I have to say that today, only 6 days of 1/2 tablet, I had more energy and less brain fog than I've had for a while! I'm hesitant to say too much, since I know these spurts of energy can be short lived, but I actually found myself singing in the shower, with energy after shopping, eagerly reading and posting on the site here, having an intelligent conversation with my son. It's da bomb!

Stay tuned, I may crash tomorrow, but this day was sweet! 

Bruxism (jaw clenching) in sleep due to INH ... brux treatment

Just wanted to note I have had bad jaw clenching in sleep since starting INH, in case this happens to others. This must be due to INH's MAOI effect. I picked up a new click/hitch in my jaw, which will resolve hopefully in a few weeks. I also find bruxism can produce a vague fog/malaise (when it is not severe enough to produce a nasty headache), and this fog/malaise has gone away now that I have resumed using my NTI-tss device. By the way, I personally find the latter effective for at least the milder range of my bruxing. I'm not sure it was 100% effective at preventing fog/malaise when I was using antidepressants (which can cause/intensify bruxing), but those effects could also have been from the antidepressants themselves, so its unclear. Unfortunately the NTI-tss is rather expensive at ~US$150 to 300 (many dentists actually ask US$800 for it, but that price is indefensible).

Should I add doxicycline to INH, rifampicin, amoxicillin?

My walking really has collapsed to an uncomfortable limp of about 300 meters.  I wonder whether I should add back the immunomodulatory doxicycline. 

The INH Blues

I haven't posted for a bit, and had a report all prepared of how I felt I'd turned a corner in the last couple months. Tonight, though, I'm "singin' the INH blues..." having just hit day 3 of adding a half of a 300mg tab each day. I'm amazed that after a year on the protocol and 7 or 8 tinidazole pulses, I have such big inflammatory reactions to adding this more potent med. But it also makes it clear that there are tissues which have not been reached as well by my continuing doxyi/zithi/naci/tini combo, hence why my progress has been gradual, although steady.

 Some good news too. I just got back from a business trip overseas which I had also done in September '05. I clearly was doing better now than in September: less fatigue, less brain fog, more resiliency from travel, quicker adjustment to jet lag and time change. This prior to starting the INH, so I know it was the accumulated result of the doxy/zith/nac/tini combo.

INH, Rifampicin, Amoxicillin

I've been on isoniazid (INH), rifampicin and amoxicillini for about 2 weeks now and my walking has over the last 2 days felt very malcoordinated and lacking strength.  I hardly dare use the gym.  My left foot burn is also quite bad and has been since the last dose of flagyli which I had just before starting the new protocol of INH, rifampicin and amoxicillin.  Has anyone else experienced a deterioration in neurological symptoms when starting the INH/rifampicin pills?

My story... read only if you have time

My story all began miles up in the air.  I was on my way to Aviano, Italy to visit a friend in the military.  It was Thanksgiving and he had leave due to the holidays so I bought a plane ticket to go out and visit him.  We went all over Italy first Rome, then Florence and everywhere in between.  Italy was great and I was in awe most of the time I was over there.  Florence had the best food I have ever tasted in my life.  My friend and his girlfriend at the time weren’t exactly the greatest hosts in the world, but I had a good time nevertheless.  I came back from Italy and many different horrible things started to happen. 


To be fair I should begin to tell that I grew up with a ton of different ailments.  With the doctor’s boiling it down to a, “I don’t know.”  I had scarlet fever when I was really young, I must have had strep throat more than anyone on this planet.  I had strep throat so much that I got immunei to Ceclor and they could no longer administer it to me anymore.  I was born with a heart murmur and saw a pediatric cardiologist for years.  I had migraines that would land my mother and father in the emergency room many a night to await an injection of something or other to knock me out, regardless of the big blue horse pills that I was on for the migraines.  To top it all off I was an over-hyper active child.  The doctor said that all of these things would go away with adolescence and indeed most did.  I continued to get strep throat and every other sort of cold and upper respiratory infection known to man until I had my tonsils removed at age 23. 

Dr. Michael Powell: A Rheumatologist Treating Cpn in CFIDS, FM, Lupus and other "auto immune" disorders

I spoke with a rheumatologist in California, Dr. Michael Powell, who is cautiously using a combination of antibioticsi in conjunction with standard therapeutics for the treatment of nanobacterium (including Cpni) in patients suffering from FM, CFSi and autoimmune disorders. His results with this treatment program have been encouraging. He faxed me some examples of patient feedback forms, excerpts from which you can see below. Recovery is not instantaneous, but tends to occur over a 6 to 12 month period. The graphs of subjective improvement are drawn from visual analogue scores compiled during each visit. When summarized in this manner these data give a time-lapsed impression of the response to treatment.

One of the interesting things he mentioned was in relation to negative patient serologyi for Cpn when other clinical signs lead him to suspect some involvement. Serologic assays for IgGi, IgM and IgA are sent to confirm infection prior to treatment. He would like to see a positive serologyi in patients before engaging them in a combination antibiotic protocol, but recognizes that patients may not have antibody reactions. This may be due to the ability of intracellulari organisms like Cpn to evade a humoral response (antibody production), immunoglobulin depletion, or other factors. In these cases, when there is a high index of suspicion for the infection without a humoral response, he tests the spouse of the partner for Cpn. He sees the "non-symptomatic" partner as a good indicator of Cpn in the patient, given the infectious nature of Cpn. Thus far, most spouses are positive when an ill family member is non-reactive.

In our discussion Dr. Powell pointed out the many similarities between TB and Cpn.  Both organisms  can evade our immune system.  Both organisms can be carried from the lungs, the original site of infection, and infect other tissues. Both require prolonged treatment with multiple drugs to eradicate the infection.  Both are sensitive to stress levels. Optimal therapy is being evaluated at various research centers and new medications for Cpn are on the horizon (see

INH and supplementsi for endotoxinsi-
Dr. Powell finds most patients improve on a standard combination antibiotic protocol for Cpn. Rheumatologist have apparently been using doxycycline for many years with success for inflammatory arthritis but there is evidence that using doyxcycline in combination with rifampin is even more effective. Some patients plateau after about 8 months of treatment he has found variations in the treatment protocol have made a difference. One protocol he uses involves the use of NACi 600 mg twice daily, INH 300 mg once daily before breakfast, and metronidazolei 500 mg twice daily pulsed with 5 days on and two weeks off.  It is essential to start each agent separately and gradually increase the dose over weeks or months as tolerated.  The use of Vitamin C 500 - 1000 mg four times daily (the half life of vitamin C is 30 minutes and little remains after 3 hours) to offset the release of toxins during therapy.  B6 is important to control INH related peripheral neuropathy.  Monthly laboratory evaluation of AST, ALT, Cr, and CBC are recommended for all who engage in this protocol.  It is not uncommon for liver enzymes to show a mild elevation during the initial stages of treatment.  Antibiotic therapy should be temporarily discontinued during periods of toxicity, should it arise. He emphasized the importance of insuring that yeast and fungal infectionsi do not overgrow during protracted antibiotic use. He recommends the use of acidophillus, nystatin, diflucan, oregano oil, and/or grapefruit seed extract as needed to prevent secondary opportunistic infection during treatment.

Covering for the possibility of yeast and fungal overgrowth during antibiotic therapy is essential.  If diarrhea develops, stool must be evaluated for antibiotic associated diarrhea (C. difficile).  This is not a simple protocol and it is best if it is guided by an experienced clinician who is familiar with the medications and methods of minimizing toxicity related to killing the nanobacterium.

A link to Dr. Powells clinic may be found on our links page. Dr. Powell does do telephone consultations by arrangement and may be a resource for those who have had difficulty finding a Cpn knowledgeable doctor in their area. He requires an initial visit with a physical examination before initiating therapy (lab work can be performed prior to the initial visit to facilitate diagnosis and treatment), and monthly laboratory testing with monthly phone consults are then the norm. Treatment of related hormone imbalances in the thyroid system and nutritional support, temporary antidepressant support as needed, and sleeping medications are useful adjuncts to the antibiotic protocol. It is necessary for patients to have a primary care physician to monitor health matters that are unrelated to FM, CFS and autoimmune disease.


In the recent posts regarding antibiotic combinations, I have not seen anything about INH. I have been on a couple different regimens (just couldn't tolerate Rifampicin) but basically since April I have been on Doxyi/Azithromycin/Amoxicillini. I'm 10 months into treatment and I'm doing okay, the Flagyli pulses are getting much easier to take.

My doctor wants to switch me to INH/Probenecid/Amoxicillin (with pulses of Flagyl of course). If you read the patent you will see that they have a whole section on INH as a novel agent that kills CPni pretty effectively.

I just thought I'd mention that INH is VERY cheap and the protocol above is very, very inexpensive as a whole. I think it costs less than just the Zithromax per month.

Liver monitoring is an issue and a lot of GPs will probably be nervous about INH just like they are with Rifampin, I am taking loads of charcoal at night and popping milk thistle during the day in large amounts to protect my liver anyway. 

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