Cathelicidins and LTB4
Just ran across an interesting study suggesting that Leukotriene B4 (LTB4) and the Human Antimicrobial Peptide LL-37 (Cathelicidin) may work in a positive feedback loop, meaning they may both stimulate each other for enhanced immunei response:
I've mentioned before how I thought using a 5-LOX inhibitor seemed to dramatically increase my infection prior to when I started CAPi therapy, and I've mentioned past studies which seemed to suggest 5-LOX inhibitors can increase infection rates, but I found this study particularly interesting.
Remember 5-LOX inhibitors, and dual COX and 5-LOX inhibitors inhibit the production of leukotrienes, including LTB4:
Also remember studies seem to suggest that Vitamin D3 likely helps induce Human Cathelicidin production (LL-37) as has been mentioned on this site before: