Case of Chlamydia Inhalation (Source Cattle)

History :

Following inhalation of particles in a tunnel in 2003-july (transport of several trucks of cattle preceded my car) I had a feverish state (starting same day) which lasted 4 days (no temperature, just important cold sweat) + drip syndrome (started not more than 1hour after exposure).

 

Before all this happened, I had  an episode of  strong coughing for a 3 months period which was probably due to exposure to bordetella pertusis (whooping cough) as titer showed quite high still 1 year later.

 

Appearance of headaches (sinusite), nausea, symptoms of oppression at upper respiratory tract + disconfort, vertigo, etc. I made several radiography which showed nothing.

 

 Symptoms over time :Drip syndrom lasted at least  for 1 year (it was reduced with local cortison treatment).Symptoms of feeling of burns (comparable at the pain one can feel when receiving an injection, needle penetrating) to foots, chest (level diaphragm both side), hands, arm, legs, occasional ocular pains.Also to note that in March 2004, I had a vein/blood vessel (located in left area chest at the top of the heart) which strongly inflated over a 15 cm length, I could not move the arm up. The symptoms regressed after 20 days of aspirin at a dosage of 3 grams/ day.Antibiotherapy :I had several antibiotherapies with :

1) Rulid - macrolid (5days) in august 2003 / result : no effect

 

2) Augmentin for 2 weeks end of september, improvement was clear but not complete and symptoms reappeared after one week cessation. Apparently (quite surprisingly) this antibio is known by experience to have an effect against those strains which have no pecto-glycan membrane !

 

Nasonex (nasal cortisone) which appeared to have helped to reduce the drip-syndrom). I also had an antibio with another macrolide (clarithromycin, 2 X 500 Mg/ day in july 2004) for 2 weeks. Do not seem fully active however has most probably got an effect.

I took it later a 2d and 3rd time, however it did show reduced benefit for me (strain resistance to this antibio is apparently common).

 I then took  doxycicline 2x 100mg / day (did not seem very effective although in some articles it appears to be one of the antibio of choice against Chl. pn.) for a 2 week periods.

I took it again with higher dosage (double) and it showed better effect the first time we used that protocol with higher dosage.

Symptoms which have always be present and still are :

Rhinitis, fatigue, headache, itching of skin and eyes, tingling and numb of extremitiesness (they spread indifferent part of the e.g. bodies, thorax),

--> impressionn of being shooted violently with a needle !

dizziness states, upper respiratory tract pains (burning), bronchitis state (a lot of secretion), etc.

 

Lab Diagnostic :

Lab Serologyi june 2004            Chlamidia pneumonia IgGi to 160 (cut off with 40)            IgA with 80 (cut off with 20)            Comment Laboratory:         IgA positive in the presence of moderate rates of IgG.

Results compatible with an active infection.

At that time Bordetella pertussis (whooping cough) showed very high titer : around 3000 (it decreased a few months later by a factor of 4. In september 2004, a new serologyi for chl. pneumoniae has been performed. IgG (anti chl. pneumoniae)increased x 4 (at 640) + appearance of IgM.  

 

Questions :

Chl. pneumoniae can it be transmitted by the cattle (sheep, bovines, others)?Is it possible with a PCRi to identify the strain with which I may be still infected, what protocol to use ?Is there a contact (Doctor / Lab) you know in the area of GenevaSwitzerland ? A serology for fever Q indicated a titer of less than 80 (for the laboratory = negative). Shall I repeat that test ?

 

Possible antibio against Chl pn. as per litterature are per order of efficacy : doxycicline , tetracycline, then erythromycine, and little ciproflaxacin. In addition it seems that antibiotherapy protocolsi to fight this type of microorganism shall have a quite long duration and be repeated several times. What is your advice (possible antibioth., test to be performed, duration of antibiotherapy, etc.) ? 

Thank you in advance for your assistance,

D. R.

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Hello D. I've no idea if it

Hello D.

I've no idea if it can be transmitted by animals or not but you do say that prior to that incident you had a pronlonged period of coughing and that may have been the start of it. I'm sure one of the experts will come along soon who may be able to answer that question.

Can I suggest you start by looking at the Getting Started section if you haven't already done so. We normally test for cpn by starting on NACi at 600mg a day and slowly ramping it up to 2400 a day. In fact the Wheldon Protocol recommends doing that for 2 weeks prior to starting abxi although it's not mandatory.

Yes this is long term treatment, you can't just take a few abxi for a couple of months. You're probably looking at 2 years or more as you need to hit the stuff that's hiding deep within your body. Some of the people on here with high cpn loads have been taking it for 4 years but many are showing remarkable improvements. The Patient stories will give you a better idea.

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NAC 2400mg. All supplementsi. Doxyi 200mg. Zithi 250mg M/W/F.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAP 20th April 2008.

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Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NACi 2400mg. All supps. Doxyi 200mg. Zithi 250mg. Metroi 400mg.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAPi 20th April 2008. First pulse June 2008

Hi Andesine,  I am living

Hi Andesine,

 I am living in Geneva (Switzerland), could you please provide me with a Doctor name who could help me with management of such protocol.

 Txs

Daniel R.

Daniel, I can't find one in

Daniel,

I can't find one in the UK! Have you tried your own Doctor? Some of them can be responsive if you give them the right information up front.

I have no idea of any Swiss kindred spirits but someone else on here may know of one or be able to advise. Hang on in there.

I have to self medicate as my GP and Neuroi won't support me. 

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NACi 2400mg. All supplementsi. Doxyi 200mg. Zithi 250mg M/W/F.
No GP/Neuro support. Self medicating with help from David Wheldoni.
Started CAPi 20th April 2008.

___________________________________________________________

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NACi 2400mg. All supps. Doxyi 200mg. Zithi 250mg. Metroi 400mg.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAPi 20th April 2008. First pulse June 2008

Hi there, OK, I will try wit

Hi there,

OK, I will try wit my Dr.

Txs

Cheers,

DR

Don't take mountains of

Don't take mountains of paperwork along with you as you'll probably send him into meltdown.  

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NACi 2400mg. All supplementsi. Doxyi 200mg. Zithi 250mg M/W/F.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAPi 20th April 2008.

___________________________________________________________

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NACi 2400mg. All supps. Doxyi 200mg. Zithi 250mg. Metroi 400mg.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAPi 20th April 2008. First pulse June 2008

dxrinaldi, You most

dxrinaldi, You most definitely can get cpni from livestock. We have a great article on this. I will look for it. Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

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Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

The following is a summary

The following is a summary of an article by Authors: Dipl. Ing. Emil Bazala, Vítìzná 588, Litovel, Czech Republic Dr. Vet. Med. Jaroslav Renda, in memoriam, Czech Republic Almost all people experience in the course of their lives a number of diseasesi. These are most often various infectionsi like influenza. Such short-term health problems are unpleasant within the period of their occurrence, and unless they leave long-lasting negative aftereffects, they are soon overcome and forgotten. There are, however, worse cases when one suffers from permanent, long-lasting, cumulative or intensive health problems. Many people, especially with advancing age, complain of long-lasting or even permanent problems complicating their lives to various extents. When evaluating health from the point of view of valetudinarianism and average life expectancy, we can get reliable statistical data. Nevertheless, a number of people have put emphasis on a category, which is not included in any statistical observation: the suffering of the ill. A healthy, or at least relatively healthy, person may find it difficult to realize the extent of suffering many ill, though seemingly healthy-looking, people experience. To be able to enjoy a full life one needs good or at least acceptable health. This makes health an irreplaceable value in the life of an individual and in the whole society. When doctors, statisticians and ecologists discuss the causes of poor health, they usually list major causes of mortality, which are cardiovascular diseases and cancer. Environmental pollution, bad nutrition, lifestyle, genetic factors, are presented as the most common factors influencing their occurrence. Some experts (and some politicians in the Czech Republic) claim that people are to a considerable extent responsible for their own health. Certain prominent psychologists even blame bad mental condition (supposedly people just imagine their health problems), which they attempt to support with the fact that medical examinations often find no abnormalities in many patients. I spent years with Dr. Renda researching the health of people working in agriculture, specifically in animal breeding, and we discovered interesting facts that can be directly linked to the health of the whole population. People working in agriculture get exercise, have a healthier environment, and eat higher quality home-grown food, and yet as our research and other sources show, they suffer from considerably more serious health problems than the rest of the population. Farmers often suffer from strikingly similar range of health problems, such as pain and ankylosis, weariness, languor, lethargy, prickling and tingling of the limbs, rheumatismi, allergies. Scientific sources world-wide prescribe these to hard work, airborne dust, draught, various gases in barn air, infections obtained from animals, pesticides. These problems also occur in the farmers’ family members not involved in agriculture, as well as in employees of biological services (animal breeders, veterinarians) and their family members. After twelve years of intensive research, analyses and consultations with experts in both human and veterinary medicine, we narrowed down the cause of a number of health problems and diseases to latent chlamydial infection. This is not the famous sexually transmitted Chlamydia. It spreads as a respiratory diseasei. It persists in an infected organism for the rest of its lifespan. After penetration into the host organism, Chlamydia permanently survives as intracellulari parasites in the cells of a number of organ systems of humans and animals. In addition to the direct effect on the host cell, they release an endotoxini. This induces permanent, most often subjective, painful and unpleasant health problems in humans, often simultaneously occurring. The findings of our research were published in veterinary journals in the Czech Republic and Germany in 1992. Due to persistent and deteriorating health problems in a majority of the examined people, we decided to continue in our research efforts and consequently discovered similar symptoms in people from urban, non-animal breeding communities, whose tests were also in many cases Chlamydia seropositive. As early as 1992, we analysed and published our research into the 27 most common and widely observed health problems in 746 workers from 31 farms around Moravia and eastern Bohemia and 146 randomly selected members of a control group from the same region, but working outside agriculture. In the group of farmers, the frequency of symptoms per person was 7.1 while in the control group (teachers, policemen, bricklayers, physicians) it was only 3.0. Of the people examined, 70.6% of farmers and 19.5% of non-farmers suffer from more than five of the above mentioned problems. Imagine what people suffering from six, seven, ten or even more simultaneous health problems feel like. These alarming facts clearly show that farmers experience poor health conditions and the situation in the rest of the population is not ideal either. The course of the disease in afflicted families: In newborns, infections may sporadically occur in the ocular region or in the lower part of the respiratory tract. There may rarely also be health problems of a more serious character. Babies generally seem to be healthy but sometimes they are restless, crying, and with sleep and appetite disturbances. In later childhood, these children can suffer from various allergies (atopic eczema, normal eczema). In periods of changing weather, they may show symptoms of fatigue, apathy, insomnia and bed-wetting until advanced age. Sometimes we observe anorexia, sporadic swelling of lymphatic nodes (most frequently on the neck) and minor nervous problems. Infected children also often suffer from neurological abnormalities such as light brain dysfunctions (LBD), manifested as reduced ability to concentrate, restlessness, torpidity (but in some patients also hyperactivity) and problems with learning. From time to time, children may also complain that they suffer from pain in various part of the body (abdomen, eyes, limbs, or neck) and such a condition is usually also associated with climatic changes, i.e. with the degree of biological stress. As a rule, these conditions occur suddenly and also disappear quickly so that the parents mostly do not pay much attention to them. From the long-term point of view, these children seem to be healthy. Rarely infected children show, similar to some adults, symptoms of other problems, including leukaemia, cancer, and multiple sclerosis. Some children also suffer from frequent infections of the lower part of the respiratory tract and of the urinary tract. In later adolescence, some subjective, weather-related health problems may occur, such as pain in the back and limbs, or fatigue. Allergies are also more frequent, especially skin eczemas. In adults, the onset of subjective problems is slow and the problems increase depending on the length of the infection, with the advancing age of the patient. Infected people show distress, anxiety, nervousness, irritability, apathy, insomnia, tinnitusi, stabbing pain in the muscles, myoclonia and twitching in other body parts, lancing pain from the spine to various parts of body, trembling of the hands, and fibromyalgiai. Back pain is a frequent symptom of latent chlamydial infection. Some patients may show various (for some physicians inexplainable) problems such as itching or even skin pain, aftertaste, a feeling of cold and itching in the bones that sometimes changes into a local pain in the bones (supposedly resulting from periostitis), occurrence of local, pressure-sensitive pain spots in various parts of the body, sudden feelings of cold or warmth not corresponding to ambient temperature, chapping of lips without an increase in body temperature. Some patients may show symptoms of aching conditions that may move from one place to another. These ‘moving pains’ and other problems result from long-term irritation of nerves by endotoxinsi (lipopolysaccharides) produced by Chlamydia. Endotoxins above all cause irritations (pain, itching, burning and spasms) of nerve endings. Irritated nerves are sensitive to even minor climatic changes and increased biological stresses. The symptom of ‘moving pain’ can be explained by specific effects of varying climatic changes on irritated nerves of respective individual body organs. After a long-term, latent chlamydial infection, the irritation of nerves caused by endotoxins can result in a wide range of health problems and severe pain. Infection can cause various organs to fail and the occurrence of serious diseases during what should have been a patient’s most productive age. Infected people and their family members have a more frequent record of serious diseases, such as cardiovascular diseases (vascular incidents, conditions resembling angina pectoris, heart pain, functional disturbances and a sudden heart attacks due to enervation disorders), diabetes, asthmai, cancer, leukaemia, blood manufacturing disturbances, psoriasis, periostitis, tendonitis, gout, neuritis and phlebitis, multiple sclerosis, mononucleosis, urogenital infections, functional disorders of the endocrinal glands, chronic fatigue syndromei, Alzheimer’s disease, Parkinson’s disease, epilepsy, serious chronic nervous diseases, psychiatric disease. A detailed, professional examination of this problem could reveal the causes of a number of serious diseases and change our attitudes towards the origins of ‘genetically conditioned’ diseases (e.g. diabetes, asthma, atopic eczema). Chlamydial infections transmitted to children from their parents, and consequently Chlamydiae then initiate in the children the same diseases their parents suffer. With advancing age, people suffering from permanent latent chlamydial infection become increasingly sensitive to even small climatic changes. In old age varying climatic changes can induce in them unpleasant, painful health problems. Some become permanently ill, suffering from long-lasting severe pains. It is not their biological age, but persistent chlamydial infection that causes these problems. Blood tests may be accurate for detecting acute infection. Many people are carriers of Chlamydia, and blood tests are less useful for chronic and latent infection. People not mounting a successful attack against Chlamydia may have low levels of antibodies. The production of endotoxins, the permanent irritation of nerves, the hypersensitivity of the infected organism, the autoimmune effects of antibodies, and the production of heat shock proteini result in the occurrence of a wide range of diseases with long-term and severe problems, painful and intolerable. Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

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Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

Good Heavens! My aunt spent

Good Heavens! My aunt spent almost all her life working with animals, mostly pigs and poultry. She is now almost completely crippled with Rheumatoid Arthritis.Sadly I suspect she is now beyond the point of return and CAPi wouldn't help her.

 

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NACi 2400mg. All supplementsi. Doxyi 200mg. Zithi 250mg M/W/F.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAP 20th April 2008.

___________________________________________________________

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NACi 2400mg. All supps. Doxyi 200mg. Zithi 250mg. Metroi 400mg.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAPi 20th April 2008. First pulse June 2008

Janice C - thanks for precis

Janice C - thanks for precis article.  Fascinating.  Not something I've ever thought about really, but makes sense.  It is also a good description for general 'infection' and C. Pneumonia issues (that have, over the years, been attributed to something else.  I have copied it for myself and also to give to my doctor here in the UK.  I am sure she will find it interesting.

M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.

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M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.

Lala found the original

Lala found the original article. It is in Czech, I think. I wrote the summary and hope I got it all right. I'm editing this to say I didn't translate it from Czech. Not that anyone thought I could! Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

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Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

well, i for one, am dead

well, i for one, am dead impressed, even without the translation (you'd have to be Superwoman thenSmile . 

I will give it to my GP and anyone else who is interested, but mostly for myself.  Since no-one seems to take any notice of my illness or dealing with this protocol (though I tell them it goes through them like a dose).  As you can see Janice I am in an irate mood due to a 'friend' telling me earlier on the phone I should just get out of bed and stop lying around and being negative, and should I be on this protocol anyway, its news to her, though I told her about it months ago (is anybody out there???).  I told her if she didn't believe i was ill that was her problem, blah blah blah.  We don't talk much about our illnesses on this website, I guess we take it as read, but I am sick of the whole darn thing, the sickness, the disbelief, the isolation, even the trawling through the medical stuff sometimes (I mean I'm the one thats ill, shouldn't a doctor be doing this for me?). 

M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.

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M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.

Blackfoot,  Here's an old

Blackfoot,  Here's an old thread for your mood. 

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

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Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

Read thread, thanks

Read thread, thanks Cypriane.  Its hard, many difficult things at once.

M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.

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M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.

Louise, a long time ago you

Louise, a long time ago you posted an article about how if people can't understand what we are going through, then they could at least be supportive. I couldn't find it again. It would be good for people who think we should just "get out of bed." Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

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Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

Interesting article. I grew

Interesting article. I grew up on a farm with lots of animals. We had several barns that I used to play in starting at around 6 years old. I have many problems that are listed. I have major climate change pain and have since I was a young teen. I have had skin exzema as did my dad all our lives. Nervousness and anxiety has kept my nails bit off to the quick at several times in my life. I was very anorexic as and teen as well as suffered with terrible insomnia in my twenties. I had lots of throat infectionsi, appendicitis and gall bladder disease in my twenties. I had mono in my teens and then developed MS in my late twenties. I have various food allergies that manifest themselves with rashes and hives. If this is true, it follows some of what I have experienced in my life. Interesting to say the least. 

SPMS< Supplementsi & NACi, Doxyi 100 mg, Azith 250 mg 3X/wk

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SPMS< Supplementsi & NACi, Doxyi 200 mg, Azith 250 mg 3X/wk, starting flagyli slowly

Full length article cited

Full length article cited here above available at this page :

http://www.cpnhelp.org/a_few_articles

very interesting.  Though I

very interesting.  Though I didn't grow up on a farm I was exposed to my uncles' farm for the summer months.  They were mixed farms so there was lots of animals including cattle.

CFIDSi/ME 26yrs, FMSi, IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#9 750mg 5.5 day, 4-25-8

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CFIDSi/ME 32 yrs, FMSi, IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#11 1000 mg 5 days 6-14-08

WOW - are we saying here

WOW - are we saying here that the primary source for transmission of Cpni is livestock?  I did not get much exposure to a farm but we did own a couple of horses when I was a child and I went horseback riding at a local stable frequently. 

Tina-MSi 37 years;EDSS 4.5   1/1/08 Wheldon CAPi; Azith 250mg 3 x a week; Doxyi 200mg daily, NACi 2000 mg daily, started Flagyli pulse 4/14/08.

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 Tina-MSi 37 years;EDSS 4.5   1/1/08 Wheldon CAPi; Azith 250mg 3 x a week; Doxyi 200mg daily, NACi 2000 mg daily, started Flagyli pulse 4/14/08.

 

Tina,  That's just one

Tina,  That's just one article.  I believe that there probably is significant transmission from livestock to humans, but it probably is far outstripped by the frequency of human to human transmission.

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

___________________________________________________________

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

The bug load at time of

The bug load at time of infection is the very important factor

+ immmune and genetic condition of the person who get infected

+ virulence (what makes the bug to be virulent, have specific infective properties against specific species, genetic population, etc) of the strain coming into contact with patient (interaction between bug virulent "factors" and subject genetic factors).

A lot of human beings have been in contact with CHL (AND have then produced anti-bodies against CHL) however certainly with low amounts of bacteria which will trigger a normal immunei response which will be sufficient to defeat the bug.

If for any reason (e.g. co-infection, immune depressed subject, "massive"amount of bugs infecting the subject at one time, etc.) the patient cannot respond with strong enough immune answer, the first defenses of the subject are "defeated" and the infection can go to chronic disease.

So what is important is not whether it is spread from human to human or from animal to human, however the "kinetic" of the reaction (taking into account all paramaters : immune function of the subject, virulence of the infective bug strain, quantity of bugs in aerosol which entered subject body(CHL pneum. being mostly spread trough air as main but not single possible vector).

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