Bromelain

What is known about the use of bromelain?  I have begun to take it, but having difficulty getting to the full dose (1000mg daily) due to the digestive side effects (intense heartburn, nausea, loose BMs).  What experiences have other had with it?  What is known of its efficacy?

I use it because it is very good as an NSAID, so it dampens my trigeminal neuralgia and saves on me taking to many ibuprofen.  I take up to 4000mg a day if and when needed, which isn't often...............Sarah

An Itinerary in Light and Shadow
Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Bromelain is a natural anti-inflammatory.... It also potentiates  antibioticsi, has mucolytic properties, as well as many other proven effects on the body and uses......  here is an informative link from a homeopathic site.

http://www.tbyil.com/bromelain2.htm<

 

JeanneRoz

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

I read the linked article and it left me a bit puzzled.  If bromelain induces cytokinesi, how is it anti-inflammatory? Especially in hypersensitivity disorders like sarcoidosis?

Sarcoidosis 12/2007; NACi 2400mg; Quercetin 1200mg; Vit C 1000mg; Flaxseed Oil 2000mg; DHEAi 25mg; Zinc 100mg; Acetyl-L-Carnitine 500mg; Prednisone 3.33mg; no antibioticsi; Vit D contraindicated in granuloma diseasesi<

I love bromelain... take about  3,000 mg or 16,000 IU's a day.  I don't have any side effects at all and take it on an empty stomach. 

What are you using it for?  My main use is as a fibrolytic enzyme, and also to potentiate antibioticsi.  

 

Thorne Research has a paper on Bromelain and it's many uses:

http://www.thorne.com/media/alternative_medicine_review/monographs/Brome...<

CFSi (EBVi, HHV-6, CMV, Coxsackie), Reactive Arthritis; mycoplasma hominis, toxoplasmosis, lyme negative, babesia equivocal. Minocin, zithromax, tindamax, mepron, lariam, bromelain, probiotics, ALA, apple pectin, etc.  IV clindamycin `1200 mg. seven days/mo

I take it for sarcoidosis.  What I am trying to find is an alternative to prednisone that will interrupt the systemic inflammationi without shutting down my immunei system the same way prednisone does (along with its numerous other side effects).  Bromelain is decribed as suppressing inflammation and up-modulating the immune system.  Certainly activating natural killer cells is good thing if you believe that sarcoid (along with many other chronic diseasesi) is fundamentally caused by a bacterial infection.  Suppressing inflammation is just as good for a chronic disease hallmarked by inflammation.  Win-win.  So far, so good.

One of the things I note in the literature is that it is thought to suppress production of bradykinin.  This would in turn suppress nitrous oxide release.  Wouldn't this cause spikes in blood pressure, vision problems and erectile disfunction?

My experiment with bromelain is kicking my butt, or more precisely, my stomach.  Nausea and heartburn have badly increased.

I am wondering what other experiences with bromelain are and if there is a more robust body of literature written by people who are not also selling it?

Sarcoidosis 12/2007; NACi 2400mg; Quercetin 1200mg; Vit C 1000mg; Flaxseed Oil 2000mg; DHEAi 25mg; Zinc 100mg; Acetyl-L-Carnitine 500mg; Prednisone 3.33mg; no antibioticsi; Vit D contraindicated in granuloma diseasesi<

Kainer, You might try putting the tablet, whole or cut inside a "000" empty gel capsule or V capsule from the healthfood store or available online to get it tablet or capsule further down into the GI tract before it disintergrates.  I have done this with NACi and abxi other have done it with flagyli with some success.
  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <
I'm taking enteric-coated caplets.  I have stopped taking at the moment because the discomfort has become so bad.  I feel truly ill.  I will come backto the bromelain once I feel better and see if my reaction reoccurs.

Sarcoidosis 12/2007; NACi 2400mg; Quercetin 1200mg; Vit C 1000mg; Flaxseed Oil 2000mg; DHEAi 25mg; Zinc 100mg; Acetyl-L-Carnitine 500mg; Prednisone 3.33mg; no antibioticsi; Vit D contraindicated in granuloma diseasesi<

Kainer, I took it several years ago before I had tinii available, as a substitute of sorts.   I'd have to look for notes or posts that I made at the time for any accuracy about my response.  I can say I felt that it was not benign and since there was little in terms of knowledge about it's use in that way, (would have to look also for the dosage and frequency that I tried) and I became a bit wary of if it because of my response and therefore I decided that to get Tini as the protocol suggests would be a better choice.  I had no gastric symptoms from it that I recall, however I only took it as a pulse substitute, so it was a matter of days, not months and I only did one pulse with it.  
  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Interesting...

I perhaps now have an idea of what a flagyli pulse feels like.  When I went to 1000mg daily, the bromelain hit me like a ton of bricks.  I stopped taking it entirely today (last dose yesterday morning), but the lingering effects are almost flulike: nausea, brain fog, muscle discomfort, fatigue, sinus stuffiness, bronchial pain.  There is no sweating, light-headedness or tightness in the chest (so no fears here if you catch my meaning), but the sharp pain in the solar plexus area was, well... disagreeable.

My history with the sarcoid includes a history of pain in the same area, and I have a history of GERDi.  I can only speculate if this may be an (or the) area of infection.  Hopefully over the next few days the symptoms will subside.

I would be interested in hearing more about your response to it.

Thanks.

Sarcoidosis 12/2007; NACi 2400mg; Quercetin 1200mg; Vit C 1000mg; Flaxseed Oil 2000mg; DHEAi 25mg; Zinc 100mg; Acetyl-L-Carnitine 500mg; Prednisone 3.33mg; no antibioticsi; Vit D contraindicated in granuloma diseasesi<

Kainer, I got the Bromelain idea from a past variation of the Cowden Support Program.  I just found a recent 2008 version and it looks like serrapeptase is in use now, bromalain is out of the mix. 

There are people that have moved onto this approach after years of Lyme tx with antibioticsi, I am aware of several who seem to be doing well and avoiding relapse through its use. 

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Hi Kainer and Louise,

Serropeptase seems to be a good alternative to bromelain for me. I use it for my sarcoidosis (2 a day) along with anti-inflammatory nutrients like zinc, vitamin C and foods like rosemary, ginger, turmeric and fish oils. So far I have managed to avoid the prednisone route.

CFSi<i< / sarcoidosis. Cpn diagnosed 2002. Doryx and nutritional supplementsi since 2002. Added NACi and zithro 2007. Flagyli pulses Jan 2009.

I also take 20mg serrapeptase daily.  I am trying another bromelain pulse.  Lets see how this works.

Sarcoidosis 12/2007; NACi 2400mg; Quercetin 1200mg; Vit C 1000mg; Flaxseed Oil 2000mg; DHEAi 25mg; Zinc 100mg; Acetyl-L-Carnitine 500mg; Prednisone 3.33mg; no antibioticsi; Vit D contraindicated in granuloma diseasesi<

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