Cpn Handbook

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Emerging Stratton Protocol 4/2008: a new approach to an old set of problems

Emerging Stratton Protocol 4/2008: a new approach to an old set of problems

Reported by Jim K

Secondary Porphyria in Cpn: Extracts from Stratton/Mitchell Patent

I thought this should be available to Cpnhelp users. This is extracted from the Mitchell/Stratton (Vanderbilt) patent:

Cpn "Quick Survey's" of Treatment Results

These are two informal surveys done a couple of months ago to get some quick answers about treatment response. They are both small numbers, hence called informal.

We had done larger surveys in prior years but the last one was too ambitious in scale and too difficult to analyze and correct errors in. I'll try again eventually with a more modest survey.


Comments on CAP variations from Dr. Michael Powell

I asked Dr. Powell to comment directly on concerns that have been mentioned over time as to whether he uses the CAPi with his new patients. I received his response a number of weeks ago but have had no time to put it together in a cogent context. But continued posts on these questions has mobilized me to get his comments to our readers here. But context is, as we say, everything.

Activity of Cholestyramine, Activated Charcoal, and Super Activated Charcoal Compared

One of the discussions over the years has been the use of binding agents to soak up fat-soluble porphyrins dumped into the digestive tract by the liver, and keep them from getting re-absorbed on their way through the digestive tract. This not only lowers the immediate porphyriai reactions, but helps over time to lower the total body load of fat-stored porphyrins. Some people with Cpni don't appear to be bothered much by porphyria and find binding agents not at all helpful, others find it life saving as porphyria is a big component of their distress from Cpn. Since some tissues like the liver and bone marrow are bigger producers of hemei, it stands to reason that Cpn infectionsi in these tissues would probably create the worst secondary porphyriai.

B-12 Deficiency in Cpn Infection: Dr. Stratton's 2005 recommendations

As I could not find this in the current Handbook, I thought I'd create it's own page so it is more easy to locate! This is from a treatment handout created by Dr. Stratton in 2005, but the information is still relevant:

Case Reports from the Mitchell, Stratton et al patent

patent 6,838,552
                             TABLE 11
Serological and PCRi<i< Responses to Combination Antibiotic Therapy
Months of
Pa- Titer Antibiotic


Some patients are prescribed Isoniazid (INHi) in their CAPi. I thought it would be helpful to have an extract from the patent materials which explains this "novel class of antichlamydial agents." INH has the potential for liver toxicity, so should always be used with regular blood tests for liver function.

Some things of note:

Antibiotic Susceptibility Tests for Three Phases of Cpn

The following is from the indicated patent.

Editor: In reading the table, "positive" means that the signal for Cpni still could be detected. "Negative" means that no signal for Cpn was detected, i.e. Cpn was eradicated in all of it's forms. The MOMP gene detected by the Vanderbilt tests is present if any of the three phases of Cpn are present. The table demonstrates the faster erradication using the INHi/Metronidazolei/Penicillamine combo with the particular cell culture being tested, and that other combinations were also effective given longer time. Please remember that this is a laboratory cell culture test, not a clinical trial.

Strategies for Finding a Doctor

At this time, we do not have a list of physicians who prescribe a long term combined antibiotic protocol (CAPi), and our policy is to maintain the public anonymity of those CAP doctors who have not made themselves public. Please do not e-mail requests for a list or a referral on the "feedback" link. We offer the following strategies and considerations, though, to help you find a doctor to treat you on the protocol.

One strategy is to try the doctors you already know. For this angle, you should prepare yourself. Understand that the doctor might be unfamiliar with the concept. It’s a plus if the doctor senses that you have a firm grasp of the concept yourself. Here’s a little "cheat sheet" on the critical points:

B12 - benefits and methods of administration

B12 information

Through the research carried out by members we have collected the following information on the benefits, forms and methods of administration of Vitamin B12.


I looked up B12 patches

Sarah's beginners Guide to Supplementation with weblinks

This useful page that Sarah compiled with information about what to get where lost its links in the upgrade, or at least it lost them on my browser. So here they are again in full.

NACi to avoid reinfection of CPni:<


B12 - essential for helping to repair CNSi damage:


B and C combined, includes adequate amounts of thiamin and niacini: <

Chlamydia pneumoniae and Rosacea: A potential link?


While the exact pathology of rosacea is not completely understood or widely agreed upon, recent studies suggest that chronic inflammation likely plays a role in many of the symptoms associated with this disease.



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