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the "easier" pulse

Paul made an entry in which he outlined a flagyl pulse that consists of a 2 gm dose taken at once. The logic behind this was that the relatively short half life would result in a very quick rise in blood level to a higher concentration than we get with the usual 5 day pulses of lower doses followed by a quicker clearing. this intrigued me and not just because I liked the idea of the higher blood concentration, but also because I was wanting a very clear worsening and clearing I could more easily quantify. I've been troubled by the slow building of symptoms at flagyl days followed by the seeming vague recovery. It always feels unsure to me. SO yesterday I did the 2gm pulse instead of starting a 5 day as planned.

I took the flagyl after I had my afternoon client at 2 pm. I went to the gym and did an easy glide (I did not push myself) on the elipse, but had significant trouble walking out. I had not taken my cane so I had to hang on to stuff on the way to the car. Sort of worse than usual. Then I went grocery shopping. OK now we see a real difference. My weak leg was very much extra weak; it was dragging. I wandered around in a fog not remembering what I was intending to buy ( I was at the store for about 1.5 hours! Foggy I tell you) my balance worse than usual and defintely I did not go back across the store when I realized I did not get bread when I was on that side. For a couple of months I've been OK with moving around the store more so that was worse. Then I got home and heated the easy dinner I bought and I got a very clear measure of how this impacts me. The loss of function was exactly like the loss I get in hot water. A hot bath makes me lose the same ground. I could not lift my weak leg it dragged the ground, I kept hanging on to the counters, walls and doors, my legs, both of them, kept losing their hold and halfway collapsing for no good reason when I was trying to stand and stir rice, making me feel very uncertain of my upright status,and I was very very clear about the worsening beause a mere 4 hours before I was "normal".

KK2's Protocol Update-1st Flagyl Pulse

Day 2 of my very first Flagyli pulse and I am waiting for the 'other shoe to drop'. No bad effects so far. On the contrary, the first thing I noticed was that the painful debilitating hamstring spasms were much improved! That's right, within an hour of that first dose I felt better! A wonderful feeling of relaxation washed over my body-particularly noticeable in the hamstring. I suppose it's too soon to make a judgement call, but so far, whoopeeee!

Any theories as to why this was so dramatic? 

Pulse 4 over.

Well, I survived Flagyli pulse number 4. Goddess, am I ever glad it's over. The aches are gone, the brain fog is clearing, standing up better, typing better. I take the weekend on doxi and azithro, then on Monday I add one NACi capsule in the morning. Hopefully the aches that brings will be gone by bedtime, allowing me a peaceful night's sleep. Pulse 5 of Flagyl will start on March 6th. Wish me luck.

Easier pulse therapy

Hi Everyone,

I have a suggestion based upon personal experience for speeding up and making the pulse therapy easier to handle. Since this has only been tried on a single individual it of course anecdotal but having tried this several different ways over several years I am fairly certain this has better efficacy and produces less adverse reactions.

Instead of taking 500 mg of Flagy (Metronidazolei) 1-3 times per day over a several day period. I have seen much better results from taking a single larger dose, typically 1-2 grams. The symptoms of a single large dose are far less than the cumulative effects of Flagly taken for several days IMOi. And the gains made by taking the single larger dose seem much more substantial.

When I started pulsing this way the reaction was very significant. I would have aches and pains and a strong metallic taste within an hour of taking this. However virtually all of the symptoms would dissipate within 2-3 days. The increase in energy and cognitive function is very apparent within a couple of days and the quicker recovery time allows one to take another pulse much sooner. I went from once a week to every other day within 2 months.

I believe the larger doses allow the Flagyl to kill the cryptic formi of Cpni as opposed to simply inhibiting it, difference between bacteriostatic and bacteriocidal. In any event this seems to work an order of magnitude better for me. I actually prefer the 2 gram doses to to a smaller 1 or 1.5 gram dose now but you might want to start as I did with 1 gram and build up to 2 grams.

BTW if anyone here tries this I would very much like to hear their results.

IMPORTANT: There is a lot of data suggesting that high doses of Flagyl are safe but you should only attempt something like like this in consultation with your physician. The recommended dosage of Flagly for Trichomoniasis is 2 grams in either a single dose or divided into 2 (1 gram) doses so I do not think safety is an issue.

- Paul

My dialog with the doctor

I could not find any doctor, who would care about my treatment in spite of the fact I was at many doctors during last year. It appeared to me nearly impossible. Finally I find one, who is a pulmonary specialist. She was the only one, who knew at least something about chlamydia and mykoplasma organism, perhaps because she was been treating hard and long term infectionsi as tuberculosis is. I discussed with her the way of Stratton/Wheldon protocol treatment and told her I wanted to follow this. I told her I already started NACi.
She answered me:
It is not proved that NAC has such a strong effect on killing chlamydia. She doesn´t like doxycyklin for long term use, because it has nasty side effects, eg. vomiting and doxycyklin has only bacteriostatic effect on chlamydia, but ofloxacin kill the chlamydia according to her. She wants me to start with azithro, after some period change to ofloxacin. And add metronidazol after two months. What to say on this? I kindly ask her to study cpnhelp materials. I will reread this server and try to find and print exact articles about NAC, doxy and fluorocholins..

Mid-pulse update.

Day 3 of Flagyli pulse 4. Doing amazingly well. Achey, headachey, brain fog yes, but all manageable. The NACi is five times worse. Sleeping is the hardest part - I ache everywhere so there is no comfortable position :-/

Next month, I go back to NAC, but slowly. Hopefully, the Ester C 500mg and ALA 100mg will help there. I'd try it now, but I'm spent out already. Payday in 2 weeks. I can hold on till then.

My mood is rather good, and I have at least some energy. Typing ability seems to improve late in the day - I still tire easily typing, but hey, at least I can type. That's better than last September.

My new cath, a size 18 French, seems to have solved my leak problems. I still have spasms, but no leaks. Just started a new antibiotic for the UTIi - nitrofurantoin-macro 100mg - so I'll have to see how this works.

Did first Tini pulse

Well I did my first tinii pulse.  The first day I took 2 capsules.  I felt an extra energy that day, but the second day.......

 

I was soo confused I could barely put away the dishes from the dishwasher.  I flew off the handle about a jewelry order gone bad.  Something I would not normally do.  I was pretty bad for about 3 hours the next day and then I took some digestive enzymes and they helped. 

 

I must say though I felt some "movement' in my left upper thigh.  That was the first place 10 years ago I had tingling sensations.  I don't know if it was in my head or not but it felt easier to lift my left leg as well.  It has been 14 days since those 2 pills and I am still not back to normal.  My mood has been up and down although nothing like the next day after the pulse!  Also, I have been feeling extreme fatigue again.

add zithromax

I added the azithromycin yesterday. So far so good. It is much harder for me to increase the naci. Whatever I take that has antichlamydial activity causes me to herx on the 4th day . I know that is a good thing but when I'm going through it my mind tells me otherwise. My husband is going out of town all next week so I am waiting until next week to add 2 days of axithromycin. What a baby I am huh?

A year down the line

I'm very pleased with my course so far.  I switched to isoniazid, rifampicin and amoxicillini at the beginning of the year and have so far completed about 11 pulses of flagyli over the year or 10 months of taking antibioticsi. (I started internet antibiotics a year ago but UK prescribed pills in April 05).   My osteopath today said my bad right leg was better.  It certainly feels better and I managed last week to hobble about 1.48 kilometers which is longer than I've managed in ages.  My left foot burn is mild and has been pretty much all year.  My night spasms are still very very infrequent.  The stiffness seems to be dissolving; it's less regular and less acute.  Compared with a year ago I have definitely improved quite a bit.Laughing

Here goes number 4.

I'm doing generally ok. My mood has been up and down recently, but it's beginning to stabilise, finally. Tomorrow I start my fourth Flagyli pulse - hopefully five gruelling days of three 400mg pills a day, killing off more CPni. Wheee!

After this week, I'll see about trying to ramp up on NACi again. That stuff's downright nasty :( but it has to be done *sigh* Maybe it'd be easier with more anti-inflammatories. I'll try it and see.

Today, I stood up without help three times already, and did some squats to exercise my legs and stretch my tendons. Still working on holding silverware - I tend to spill one spoon in ten, not great but tolerable. I'm thinking about doing some lifting, too - a quart jug of water should be a decent start, to get some arm strength back.

A tentative schedule

OK, I've been off NACi for two days now, and my all-body aches are gone. However, I used to take NAC once, daily, along with ALA and vitamin C, with no aches. So, I'm planning to re-add NAC, but starting at 1 capsule each morning, along with my vitaminsi. I'll get some 150mg ALA and 500mg Ester C soon, and then I'll give NAC another shot.

Starting Monday, I plan another Flagyli pulse - three 400mg pills/day, for hopefully 5 days, in addition to the doxicycline 100mg twice daily and azithromycin 250mg M-W-F. The next Monday, I'll take one NAC 500mg, doxi and azithro, then a week of just doxi and azithro, then another Flagyl pulse but this one will use 500mg pills.

If all goes well, I hope to add Ester C and ALA, then bring the NAC to two capsules daily. Soon, I'll get the d-mannose, acidophilus and pro-biotics, and start adding them to my daily pill pile.

Entsol anyone?

Just wondering if the chronic-sinus'ers, like myself, have tried this new nasal irrigation product??  I imagine the E-N-T in the name refers to the obvious....

 

I bought the reusable Entsol squeeze bottle and a box of hypertonic salt solution packets.  I tried it for the first time one wk ago--Wow that stuff stings!  I'm not sure just how hypertonic it is, but it is beyond my pain threshold.  Maybe it's just me and my always sensitive nose.  But I have had increased sinus problemsi ever since--I can't tell yet whether it has only irritated, or if maybe it has forced open the 'back 40'....lol! Tongue out

Curious if anyone else has tried it.  Thanks.

Niacin

Yup, I do believe it is the niacin">i. Took Niaside about 8pm. By 10  I had developed a rash on my face, neck, hands , arms, legs and back. didn't appear to be any on my trunk. It grew redder and redder for about an hour and than begin to dissipate..

Marie/Gail 

To pulse or not to pulse...?

Here I am at about 4 months on the Wheldon protocol [for msi].  Though no change in meds--still the standard doxyi/azith schedule, I have experienced a pretty rough month.  I do feel fortunate as I have had a healthy season--no colds or flu--even when my kids were sick!! [Which is truly amazing for me, the sicky of my family].  However, I feel a bit "fuzzy" and tired and this concerns me as it seems like an exacerbation. Cry  I have also gained 5 unwanted pounds since Dec. 

 Three wks ago, it was incredibly tight and painfully spastic hamstrings[> on my weaker left leg].  Over the past 3 weeks of unnerving spasms and the need for more sleep meds, it has evolved into a fatigue with weak-ish legs, and poorer balance.

A realization

I think I now grok why I'm having "brain fog," something I had only before seen during an exacerbation. This fog happens because the CPni is dying off.

My MRIs show that all my lesions are in the brain. An exacerbation involves attacks that kill off brain cells, causing fuzzy thinking. Taking the ABXs and supplementsi kills off CPn and infected cells in the brain, causing the same fuzzy thinking. It took me months to figure this out, thanks to fuzzy thinking.

Another note here - even Sarah started and stopped ABXi several times in the beginning. Nobody is Superman, myself included. With that in mind, I'm to take a break soon, for one week only. I really need a full night's sleep without all-body aches, and a few days with no brain fog. I ***WILL*** re-start after a week, on the following schedule:
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