azithromycin and ReA

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1755135/<

Conclusions: This large trial has demonstrated that prolonged treatment with azithromycin is ineffective in ReA.

 

http://www.medscape.com/viewarticle/537923<  

"This large trial has demonstrated that prolonged treatment with azithromycin is ineffective." "The only possible exception could be verified chlamydia-induced arthritis, because some previous controlled clinical trials have indicated a benefit from prolonged (12-week) treatment with tetracyclines."

Last night I again couldn't stand up from bed because of horrible pain in knees. Also my hips and right elbow hurt. After taking ibuprufen it was better after a few hours. I wanted to know what this bad reaction in my knees meant. Are all the reactions positive or negative? I always thought they were positive. Now I am not so sure about it. I searched and found surprising information.

But these trials were done as monotherapy. And this can make the difference.

 

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi.Since May 2013 without abxi.

Evita, I think the fact that the treatment was only for thirteen weeks is as relevant if not more so than the fact that the treatment was a monotherapy.  It is reminiscent of the Woessner trial of roxithromycin for MS, found to be similarly useless but only given in three six week cycles over the period of a year.  http://www.springerlink.com/content/d8lk7402338677x1/<

No wonder the response by David and Stratton was so disparaging.

My view is that both abxi might well work, but you have to take what suits you best: just because you are suddenly in agony when taking azithromycin does not mean that it is going to work better......................................Sarah

A  Journey through Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Now I am sure the links above are not so good. I was so bad yesterday that I didn't really realize the most important thing - short term trial and you, Sarah brought me back to understanding. Yesterday I was the third day after Monday's and the last azi I took. Yesterday evening I came back to roxi. I am taking now 2x150 mg I would like to start the next pulse tomorrow and sometime after the pulse I'll try one dose 300mg. I didn't want to take 300 mg right now as I had bad reactions from azi and I started taking 200 mg doxyi in one dose. Doxy no problem as I had no problem before when I was taking 200 mg in one dose. I am just afraid that I might have more dizziness on 300 mg roxi and this is also the reason I am postponing it a while.

Azi seems to be too much strong for me. I had a bad porfiric attack yesterday, I was much depressed I cried for nothing and at night my  urine was reddish. I knew yesterday that porfyria was the problem so I took immediately more charcoal and more glucose. In the evening I was little better but at the night the porfyria was confirmed. I could manage everything - a porfyric attack, pain in joints but I can't manage not being able to stand up. Maybe I could take azi when starting slowly once a week and adding according to the reactions but I don't think it's clever to do so after almost 3 years on CAPi. Maybe after the next year or more I will be able to tolerate azi and I may defeat arthrititis with roxi and rifampicin. Now it's just a speculation.

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi.Since May 2013 without abxi.

Evita

As always, you have my heartfelt empathy.  I see that you are on 1200 mg NACi - maybe you could increase it.  I know so well the awful joint pain - my neck is still being "worked on", but all the rest is gone!  Really, really amazing. 

At Arttile's suggestion I began cutting Azithromycin in half and taking one-half each night.  It has made a big diffenence.  I used to be flattened for a good number of hours each MWF.  It was still a strong reaction when I went to half, but has become better with the months to the point that, for example, I mowed all day yesterday about four acres (five to six hours) of pasture and lawn.  The temperature was 97 or 98, with a heat index over 103.  The way I was going a few years ago, I could not function in such heat, even though I grew up in west Texas and rode my horse all day in 100 plus, which, of course as we all know, has nothing to do with how we do in heat now!.

As for all the bad things that you experience on Azi and the others -  there is probably no way around them.  You simply have to get through them - that is how we get from here to there, I think.  You may be able to lessen them, but they happen because this bug never goes quietly, only kicking and screaming - always violently.

Over the years, I took charcoal, too.  As you say, there is no doubt that it takes out the trash.  I still take it, but only need it every week or ten days - far beyond the daily intake of five years ago.  Sometimes it is hard to realize that all the continuing insult to our bodies and brains will get better.  It does, and is so worth it.  Every bit with which you assault this enemy counts.

Rica

 

 

3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Thanks Rica. I know that without pain there is no improvement. I can tolerate any pain and anywhere. I learnt to tell an ugly word when sudden strong pain comes and it helps though I always hated telling such words and hated to listen to it. But I can't really tolerate not being able to stand up and when there is an urgency and you can imagine the disaster. Now I realize there is not only the pain which prevents me from standing up because if I told my word I would stand up. But my knees refuse to work, to lift me and to hold me then. As if they weren't. Now I try to get to 300mg dose of roxi and I hope this should work better for joints than 2x1500mg. And then I will see. Hopefully I will see something. But what's interesting I think my legs are stronger after azi and that's why I am unhappy the azi makes me so big problem with knees.

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi.Since May 2013 without abxi.

Rica, I know that Evita won’t thnk that I am trespassing on her blog by saying this, but I really disagree when you say what amounts to “no pain, no gain.”  It just isn’t true and many people are put off even trying CAPi because they don’t like the thought of the pain.  I have a very low pain threshold but luckily a couple of weeks of reflex sympathetic dystrophy was all I had to endure on about my third pulse of metronidazolei.  As can be seen by my signature, this didn’t stop me from improving.  Therefore I will keep on advising people to try roxithromycin if they find azithromycin too hard and the same with tinidazole as compared to metonidazole.

Azithromycin and roxithromycin are very close cousins but the main difference is that azith is so formulated that it is taken every other day because of its longer half-life.  If someone is on longer treatment  it makes sense to me to take the softer option...................................Sarah

A  Journey through Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

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