Azithromycin and Breast Cancer?

My sister has FMSi and has been on azithromycin for a while. Although she has been improving on the abxi she recently stopped taking it. She did so because she had heard (forgot to ask where) that azi doubled your chance of developing breast cancer. I have never heard that. Has anyone here heard that? I'd hate to see my sister give up on eliminating her FMS (and the potential other problems Cpni could cause her in the future) out of fear of developing cancer, especially if it's a myth. We don't have a history of breast cancer in our family so this supposed risk increase applies to the general population I guess, not just specific risk groups.
 

Sunni, I haven't heard this either, but she ought to ask herself what are the risks of developing breast cancer in the first place?

This is the risk of developing breast cancer at any particular age:

  • Age up to 25: 1 in 15,000
  • Age up to 30: 1 in 1,900
  • Age up to 40: 1 in 200
  • Age up to 50: 1 in 50
  • Age up to 60: 1 in 23
  • Age up to 70: 1 in 15
  • Age up to 80: 1 in 11
  • Age up to 85: 1 in 10
  • It is taken from here:
    If she is 40 she has a one in 200 chance of developing the disease, so if this did double the risk, it would still only be a one in one hundred chance: 1%, so not very much.  If she is 85, the chances chance to 1 in 10, but even there, most cancers are benign or slow growing even at that age.............Sarah

    An Itinerary in Light and Shadow

    Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

    It is certainly not true.

    http://cebp.aacrjournals.org/cgi/content/full/15/11/2102

    Cancer Epidemiology Biomarkers & Prevention Vol. 15, 2102-2106, November 2006
    © 2006 American Association for Cancer Research
    Antibioticsi and Risk of Breast Cancer: Up to 9 Years of Follow-up of 2.1 Million Women

    Antibiotic use has been associated with risk of breast cancer in previous reports. Using Cox proportional hazards analysis, we evaluated this association in 2,130,829 adult female subscribers of a health care program according to their receipt of prescriptions of antibiotics from outpatient pharmacies. Hormone use was taken into account. Altogether, 18,521 women developed breast cancer in up to 9.4 years of follow-up. Use of any antibiotic was associated with slightly increased risk [hazard ratio (HR), 1.14; 95% confidence interval (95% CI), 1.10-1.18] but there was little, if any, evidence of dose response, with HR of 1.17 (95% CI, 0.97-1.42) for >1,000 days of use compared with no use. The only two weakly associated antibiotic groups (HR >1.10 for >100 days of use) were tetracyclines and macrolides with HRs (95% CI) of 1.23 (1.11-1.36) and 1.16 (0.98-1.36), respectively. An association of lincosamides with breast cancer in an earlier, smaller database was not confirmed, but follow-up was too short in the present data for adequate evaluation. Medical record review suggested that acne and/or rosacea could be the underlying factor, associated with long-term antibiotic therapy and found by others to be associated with risk of breast cancer. Although causality cannot be ruled out, the observed associations of antibiotics overall, tetracyclines, and macrolides with breast cancer were weak and could be explained by uncontrolled confounding by the diseases being treated or by other factors. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2102–6)

    We conclude that use of most antibiotics is associated with little, if any, increase in risk of breast cancer in up to 9 years of follow-up. Use of tetracyclines and, to a lesser extent, of macrolides, especially long-term use, showed evidence of a weak association, of uncertain causal significance. The underlying explanation may be an association of acne and/or rosacea with both use of these drugs and risk of breast cancer. Longer follow-up in the current data is needed to evaluate the association of lincosamides with breast cancer risk found in an earlier cohort.

    Their inclusion criteria

    Cured of multiple sclerosisi, stopped the Wheldon's protocol in Nov,2008. Use only LDNi.

    And I feel compelled to add my experiential but uneducated response: I have had a bi'lateral mastectomy and am about to undergo the last phase of reconstruction. I have also undergone four plus years of abxi treatment for galloping PPMSi. Tell you what - the choice is easy for me - do you mammograms, eat well, take all your meds. I'd much rather take "the cure" with all the attendent bad days than have PPMS.

    3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

    For what it is worth-I had breast cancer BEFORE I started abxi therapy.

    Lori 

     
    Started Vanderbilt protocol 1/9/08  Rifampin once a day, b12 injection monthly , vitamin Di 50,000 IU weekly
    I had lobular carcinoma insitu before starting CAPi. Hasnt CPNi been linked with breast cancer? I would definately take my chances.  if she is uncomfortable taking azith, she can switch to biaxin..

    Mphs, TN. CFSi, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpni, myco, EBVi, CMV, HHV-6. Capi began in 6/07. NACi 2400mg, minoi 100mg bidi, biaxin 500mg bidi. cytomel, flagyli bid continuously.

    Sharon, yes I think it has been linked to cancer, so damned if you do and damned if you don't.  At least I have control over ABXi, I can decide to take them and I will continue because I want to get better.

    Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.

    Don't worry guys

    > Use of tetracyclines and, to a lesser extent, of macrolides, especially long-term use, showed evidence of a weak association, of uncertain causal significance. The underlying explanation may be an association of acne and/or rosaceai with both use of these drugs and risk of breast cancer

    Basically even they are saying that the chances are there is some underlying causal factor which causes people to use long-term abxi, and which precipitates them to breast cancer. Chronic infection (e.g. with Cpni) would be the most likely causal factor. Bottom line is not that abxi cause cancer, but that people who need to use abx have bugs that cause cancer. 

     

    Hunter: Don't think - experiment

    The important line from LifeontheIce's earlier post is:

    "We conclude that use of most antibioticsi is associated with little, if any, increase in risk of breast cancer in up to 9 years of follow-up. Use of tetracyclines and, to a lesser extent, of macrolides, especially long-term use, showed evidence of a weak association, of uncertain causal significance."

    And I wish I could have responded as succinctly as Garcia did.  It was perfect.

    The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

    Comment viewing options

    Select your preferred way to display the comments and click "Save settings" to activate your changes.