Cpnhelp.org - Chlamydia Pneumoniae Treatment

Marysia, your experiences are very similar to mine. I got my walker AFTER months on flagyli. I had a year before that, in early 03, gotten my cane, both of which are gone from my life now. At that time I had no idea what was happening and that I would get better.

 

Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyl total 49 pulses NC USA

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Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 52 pulses LDNi Rifampin 8/08 again NC USA

Mary, I believe you have a diagnosis of Lyme disease, in which case you may know that paralysis is a possibility.   Read here.   The fact that antibioticsi may have precipitated some paralysis is not surprising, inflammationi often follows, and inflammation would cause the nerves to work less well than they should.  

In my non-medical opinion, it suggests that when you start the treatment you should take it cautiously, gradually ramping up with one antibiotic before adding another.

Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Thanks Katman and Michele.

Katman, did you look into porphyriai as the cause of your difficulties walking?  Were you experiencing partial paralysis would you say?  Glad it's better!

Michele, the strange thing for me with respect to my Lyme treatment is that it only happened on certain meds.  It seems that either those meds go after deep infection causing nerve problems in a herx, or there's a rare or unique-to-me allergic reaction to those meds (not supposed to have those side effects according to the Rx literature for Tinii, Flagyli, or Diflucan), or it could be related to porphyria and infection.

I'd love to figure out which it is so I can make further treatment plans.

 

Diflucan is an antifungal rather than antibacterial, like Flagyli and Tinii, but it does interfere with P450 liver enzymes. Could this be a factor? Load on the liver will also increase porphyriai, as many of the hemei producing cells are there. 

CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, INHi 150mg, Magnascent Iodine 20 drps/day, T4 & T3

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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3

 Marysia- It just dawned on me that there was a German protocol for Lyme's that used high dose Fluconozole, so perhaps that's what you were using it for? If you were killing Borrelia with it, you might get neuroi-inflammationi from that, just as when you kill other bacteria in the nervous system with flagyli or tinii.

CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, INHi 150mg, Magnascent Iodine 20 drps/day, T4 & T3

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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3

Jim - I think you meant this one

Schardt FW.

Betriebsarztliche Untersuchungsstelle, Bayerische Julius-Maximilians-
Universitat, Wurzburg, Germany. Fritz.Schardt@m...

Eleven patients with neuroi-borreliosis had been treated with 200 mg
fluconazole daily for 25 days after an unsuccessful therapy with
antibioticsi. At the end of treatment eight patients had no
borreliosis symptoms and remained free of relapse in a follow-up
examination one year later. In the remaining four patients, symptoms
were considerably improved. At the end of therapy immunei reactivity
(IgMi+) disappeared in three patients. Since borrelia spp. are almost
exclusively localised intracellulari, they may depend on certain
metabolites of their eucaryotic host cell. Inhibition of P450 and
other cytochromes by fluconazole may incapacitate Borrelia upon
longterm exposure.

PMID: 15337633 [PubMed - in process]

Daisy CAP 5/07.  Minoi, Roxy, Diflucan Round 2 started 1-31, Rifampin, Bactrim DS,  Novantrone, Doxyi, Azith

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Daisy - Husband on CAPi 5/07.  "When Going Thru Hell, Just Keep Going", Winston Churchill

 Yeah, that's the one. I know someone who did this protocol for a while. Used up a lot of fluconozole, but didn't help them much with Borrelia.

CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 500mg MWF Azith, Tinii 1000mg/day pulses; Vit D1000 units, INHi 150mg, Magnascent Iodine 20 drps/day, T4 & T3

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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3

Thanks Jim and Daisy,

I had read about the Schardt Fluconazole protocol for Lyme and hoped I might kill some Borrelia as well, but primarily I was going after yeast after some indications of possible systemic yeast infection showed up (more details below if helpful).

Jim, you had some interesting perspectives. Do you think that the die-off of other infectionsi besides CPNi could trigger the secondary porphyriai as well? I'm curious to know the answer to that one, especially since I haven't had a CPN test done yet and don't know whether that'll be the main culprit to look at.

Your idea about porphyria perhaps being triggered by liver overload with the Fluconazole rather than by what it was killing is also interesting. That may explain why I could have similar reactions to categorically different meds and also help me to fine-tune where to look for explanations. I need to read more about the P-450 pathway as that keeps popping up. Thanks for the good ideas!

I appreciate all the feedback.

Cheers,

Marysia

(Last summer I had been doing great after a year and a half on various CAPS aimed at Lyme and co-infections and I estimated I was at 70% recovery from physical symptoms. I was swimming several miles a week and going on 3 hour mt. bike rides and feeling the best physically that I had in years.

I stopped my antibiotic protocol of Bicillin, Doryx, and Zithro in order to address the yeast which we thought could be complicating my Lyme symptoms.

So, I sidelined to treat yeast for a few weeks with Diflucan alone and everything went to hell. I had a major increase in sugar/carb cravings the first two weeks on the Fluconazole and at first gave into it.

Then I buckled down to cut sugar out to starve the yeast in the 3rd week on Fluconazole and on day 24 I had what I think now was an acute intermittent porphyria attack. I experienced partial leg paralysis and other neurological symptoms (albeit with no abdominal pain which seems strange). I've had nerve pain and autonomic nervous system dysfunction (extreme fight or flight responses, like almost passing out, triggered by little things like a stubbed toe) that have been slow to heal and are lingering still after 6 months.)

CAP for Lyme started 02/06. Dx: 10+yrs Lyme Syndrome symptoms. Protocol: various helpful CAPs until Diflucan disaster, possible porphyria 08/07. Currently only taking supplementsi: NACi, Acetyl L-Carnitine, CoQ10, Alpha Lipoic Acidi, Vit D, DHA, Vit E, Selenium, Vit C, Gingko Biloba, B-complex, Theralac probiotic, Saccharomyces boulardii probiotic, MSM, Magnesium, Evening Primrose Oil, Milk Thistle, and now starting activated charcoal and Quercetin.

 

Marysia, I also use fluconazol when my problems with candida increase. I always use just one dose- 200mg. It gave me stronger herx, than I have from my regular pulses of tinidazol- and also nerve pain and depression. I do not know, why...maybe fluconazole is also killing something. In Slovakia some patients are treated with fluconazole and combination of antibiotic against cystic form of borrelia. I also noticed, that such strong reaction I have only in combination with CAPi antibioticsi. I have never had such reaction before CAP in spite the fact I was treated with fluconazol alone for couple of months. Prague, The Czech Republic, On Wheldon protocol for Cpni and Mycoplasma since 02/18/2006.

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Prague, The Czech Republic, On Wheldon protocol since 02/18/2006, CFSi and many problems 30 years (cpni and mycoplasma), 3rd year on protocol- doxyi, azi, tinii pulses