Cpnhelp.org

Loulou,

  Seasons Greetings to you as well.  Have you thought of rotating Doxyⁱ to Minocycline and / or Roxyⁱ to Clarithromycin.  You have been on the Wheldon Protocol for a while now on the same antibioticsⁱ and it may be helpful to swap one out now.  I have read Dr. Stratton mentions going to Clarithromycin is a smart move.  

   Are your vitamin Dⁱ-3 blood tests on the high side? 

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

I am presently on doxyⁱ, biaxin, rifampin. Also NACⁱ. Supplementsⁱ daily away from antis.

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diagnosed MSⁱ Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyⁱ 100 mg. 1BID. roxyⁱ.150 mg.? BIDⁱ,adding rifampin soon, pulsed tiniⁱ. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNⁱ),NACⁱ, nystatin, major wheldon supplemrnts daily,

Oh ya, forgot M,W,F zithromax.

I think that's from Stratton. So DW, Stratton. I guess I'm following part of each protocol. Looking for that light at the end of the tunnel.

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diagnosed MSⁱ Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyⁱ 100 mg. 1BID. roxyⁱ.150 mg.? BIDⁱ,adding rifampin soon, pulsed tiniⁱ. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNⁱ),NACⁱ, nystatin, major wheldon supplemrnts daily,

Loulou, go as low carb as you can in your diet -- get most calories from fat.  You must not eat sugar and wheat products. Don't supplement niacinⁱ but do supplement B1, B2, B5, B6, C.  Melatoninⁱ at bedtime, moderate vitamin Dⁱ in the morning.  Vitamin K2 and cod liver oil with vitamin A also, about 5000 IU retinoic acid per day.  Lots of NACⁱ. Plenty of seaweed in the diet.

I do believe diet is as important as antibioticsⁱ.  I don't think antibiotics alone will work.  You have to help your immuneⁱ system out.

Loulou,

   What was your reaction to NACⁱ?

   Have you taken a Cpnⁱ antibody panel IgGⁱ, IgM, IgA?  What lab if so?

   Was your M.S. diagnosed with a Lumbar Puncture?

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

In answer to questions thus far:

No noticeable reaction to NACⁱ.

I have never taken a CPNⁱ antibody test.

My MSⁱ was diagnosed with an MRI.

Paul, what is the retinoic acid supposed to do?I do occasionally eat wheat products, mostly high fibre stuff.You sound like a doctor.

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diagnosed MSⁱ Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyⁱ 100 mg. 1BID. roxyⁱ.150 mg.? BIDⁱ,adding rifampin soon, pulsed tiniⁱ. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNⁱ),NACⁱ, nystatin, major wheldon supplemrnts daily,

Hi Loulou, I am a scientist, not a doctor. 

Retinoic acid (vitamin A) stimulates several nuclear receptors, most significantly the Retinoid-X-Receptor (RXR).  This is important because vitamin Dⁱ acts through the Vitamin D Receptor (VDR), and in order to operate the innate immuneⁱ system against intracellularⁱ infectionsⁱ, a "heterodimer" transcription factor composed of a molecule from the VDR (released by vitamin D activation) and a molecule from the RXR (released by vitamin A activation) is needed to generate anti-microbial peptides. 

Activation of the RXR by vitamin A also causes upregulation of gene expression for the VDR, increasing the count of vitamin D receptors, which is good.

So, if you're vitamin A deficient, which many people on low-fat diets are, then your immune response to intracellularⁱ infections will be impaired.

PaulJ,

 I recall reading somewhere that Vitamin A intake is very important when supplimenting D at high levels. If I recall correctly, A is crucial to preventing D toxicity. Does that fit in with what you're saying here?

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CAPⁱ started 10/09 - Doxyⁱ 200mg, Azith 250 MWF, 1 Flagylⁱ pulse. Empirical CAP on suspicion of CPnⁱ or tick-borne infection. Primary symptoms are chronic sore throat, muscle pain (jaw, neck, trapezius, all on right side), rosaceaⁱ, joint pain.

Wheat germ agglutinin (WGA) blocks the VDR.  When you eat wheat, WGA passes into the blood, is internalized by endothelial cells lining blood vessels within 12 hours, and reaches pericytes and nerve cells within 24 hours.  It is typically destroyed by lysosomes within 48-72 hours, but some people are less good at this than others.  So it selectively tends to locate in neurons and endothelial cells. 

Blocking the VDR impairs the intracellular innate immuneⁱ response, helping CPnⁱ and other infectionsⁱ to proliferate.  So eating wheat, if you have a CPn or similar infection, promotes (a) atherosclerosis and (b) neuropathy/neurodegeneration for about 2-3 days after you eat the wheat.  Of course, if you eat wheat every day, this will continuously promote neurodegeneration.

Best to eliminate wheat entirely.  Among starches, rice and potatoes are neuron-safe, so far as we know.  Fruits are also fairly safe.

JJ - The idea that vitaminsⁱ A, D, and K2 need to be in balance and that toxicity is greatest when one is in high supply and others are deficient has some experimental support.  I wouldn't say that vitamin A prevents vitamin Dⁱ toxicity, but it's certainly a good idea to keep them in balance.  Epidemiologically high vitamin A and low vitamin D, a common condition, is associated with poor outcomes; probably high vitamin D and low vitamin A, an uncommon condition, also would be.  I recommend vitamin K2 supplementation also if you're going to do A or D.

Paul,

 

Why no addiitional niacinⁱ?  I take it in my Vit B Complex.  I'm on azithromycin for asthmaⁱ.

 

Brian

NAD+ is the rate-limiting factor for bacterial metabolism, and niacinⁱ is the precursor for NAD+.  So niacin promotes bacterial metabolism.