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Anti-Alzheimer's Mechanism in Omega-3 Fatty Acids

Submitted by Jim K on Wed, 2008-01-02 09:37.

As Alzheimer's is a Cpni associated disease, an many here are treating various neurological manifestations of Cpn infection, I thought these findings would be of interest. A brief quote here, and then the links for the article:

Reporting in the December 26, 2007 online issue of The Journal of Neuroscience [see abstract], Greg Cole, professor of medicine and neurology at the David Geffen School of Medicine at UCLA and associate director of UCLA's Alzheimer Disease Research Center, and his colleagues report that the omega-3 fatty acid docosahexaenoic acid (DHA) found in fish oil increases the production of LR11, a protein that is found at reduced levels in Alzheimer's patients and which is known to destroy the protein that forms the "plaques" associated with the disease.

 

The plaques are deposits of a protein called beta amyloid that is thought to be toxic to neurons in the brain, leading to Alzheimer's. Since having high levels of LR11 prevents the toxic plaques from being made, low levels in patients are believed to be a factor in causing the disease.

..."We found that even low doses of DHA increased the levels of LR11 in rat neurons, while dietary DHA increased LR11 in brains of rats or older mice that had been genetically altered to develop Alzheimer's disease," said Cole, who is also associate director of the Geriatric Research Center at the Veterans Affairs Medical Center.

 

To show that the benefits of DHA were not limited to nonhuman animal cells, the researchers also confirmed a direct impact of DHA on human neuronal cells in culture as well. Thus, high levels of DHA leading to abundant LR11 seem to protect against Alzheimer's, Cole said, while low LR11 levels lead to formation of the amyloid plaques. (italics added)

 

 

 http://www.immunesupport.com/library/showarticle.cfm?id=8597&T=CFIDSi_FM&B1=EM010208C

http://www.immunesupport.com/library/showarticle.cfm?id=8598

 

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CAPii for Cpni 11/04. Dx: 25yrs CFSii & FMSii. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tiniii 1000mg/day pulses; Vit D2000 units, T4 & T3

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  Interesting Jim, and one

Submitted by Sarah on Wed, 2008-01-02 14:05.
 
Interesting Jim, and one more thing along with D3 and chlorella to tell my mum to take: she is, after all continually saying that she can't be expected to remember things because of her age.........Sarah
An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MSii in June 2007, after four years, three of which intermittent.   Still slowly improving and no exacerbation since starting. EDSSi was 7, now 2, less on a good day.Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still slowly improving and no exacerbation since starting. EDSS was 7, now 2, less on a good day.

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Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after nearly four years, three of which intermittent.   Still slowly improving and no exacerbation since starting. EDSSi was 7, now 2, less on a good day.

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