and now time for something different.....metronidazole anyone?

Thank you sir, may I have another?  Yes, another Flagyli pulse....the 15th to be exact.  Yes, I'll wash it down with some water, thanks.

Okay, my prescrip for Flagyl was filled this week and I started pulse 15 today.  I need to call the pharmacy and see if the recieved my prescrips for INHi and Rifampicin.  My doc and I discussed it by email and he said he would have his nurse call it in.  I was expecting him to mail them to me as that's how he did the first set of prescrips, but whatever works.  I have to admit to being a bit timid about starting on two more antibioticsi since I'm on 3 already (4 if you count NACi).  I plan on starting Rifampicin next weekend and INH on my next pulse (16).

In the mean time, more observations about my progress.  Yes, still very subtle things are happening.  It is damned hard to know for sure whether I'm imagining things, but I think I've been getting more resistance/tolerant of heat at times.  Today the temperature outside is 98 F and it definitely wasn't affecting me as much as it has in the past.  Needless to say, I didn't hang around outside to really put it to the test, I got back inside into air conditioning as fast as I could.

That's the thing.  It's been 7+ years since I was living without the effects of MSi in my life.  I'm so apprehensive and fearful of the affects that I'm fearful of experiencing the benefits of CAPi as I might not be better much if at all.  I never have had any real reaction to the Wheldon protocol, it's by and large been a walk in the park for me.  Well, with the one exception at the beginning of July; however, I really don't know if that was the CAP or heat or a combination of things.  I don't seem to be getting affected the same way - today on day one of pulse 15 - as I did on day 1 of pulse 14.  Of course, I have yet to take the second dose of the day, so maybe that will change it.

I haven't forgotten about the issue with respect to the penetration of antibiotics through the blood brain barrier (BBBi).  I was going to go research articles and haven't done that yet.  Admittedly, this past month has been a busy one but I will get to it.

I also need to research information about Rifampicin and INH, and what to expect when taking it.  I've heard from my doctor that Rifampicin tends to turn everthing orange.  That sounds to me like the effect of flagyl, which has never really caused much color change in my case.  So I don't know.  I guess time will tell.  Just another task on the to do list.

Comments

John, leaving aside what

John, leaving aside what targets what and where, the main reason for not abandoning at least doxycycline if you are taking rifampicin and isoniazid is because you will feel the lack of imunomodulation.  Believe me, if you want to continue working this is not a good idea.  

Also, taking rifampicin by itself (pulses of flagyli or isoniazid don't count) you are tempting resistance in the pathogen, which can happen very quickly.  DW never prescribes it for anything in this manner.......Sarah  

An Itinerary in Light and Shadow  

Stratton/Wheldon regime since August 2003, for aggressive secondary progressive MSi.  Intermittent therapy after one year. 2007 still take this two weeks every three months. Still slowly improving with no exacerbation since starting. EDSSi was 7, now 2

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

 John- It looks to me that

 John- It looks to me that INHi is effective against the replicating phase. I've finally posted this from one of the patents, and I think it shows clearly their findings. Link Here<

 INH does not only clear Cpn from macrophages. It simply was found, in combination with flagyli and amoxi, to clear Cpn the quickest and most effectively from these cells. If anyone looks up tissue penetration of INH (including BBBi) let us know, so we can better understand what tissues it acts in.

The sole reason for pulsing it with the flagyl, as far as I recall from conversation with Dr. Stratton, is that done this way it would have minimal liver toxicity from the oxidizing effects of the drug itself. It can be taken, as in my case and in other diseasesi, long term. 

CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 300mg INH, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Taking a break from continuous protocol)

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Rifampin targets RBs too,

Rifampin targets RBs too, not just the conversion from EBi to RB. However, I don't see any reason to stop the doxycycline or azithromycin. Redundancy is a good thing, especially when dealing with an antibiotic as vulnerable to resistance developing as rifampin is.

Jim             

Jim             

Thanks for the suggestion and info.  The way I was reading most people's message, it sounded like the combo of Rifampin and INHi was really a bear or  could be.  I still believe that, don't get me wrong, but it's interesting to note that the two have been used in combination before.

The suggestion of possibly discontinuing the doxy/azi combo eventually has me a little confused.  Those two target RBs whereas Rifampin targets conversion from EBi to RB, and my understanding is that INH goes after cryptic Cpni.  Wouldn't I be leaving myself open to discontinue doxy/azi or are you suggesting the the RB load would be low enough to do that? 

Also, correct me if I'm wrong but doesn't INH mainly clear macrophages and monocytes?

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

 All I can say is that Dr.

 All I can say is that Dr. Stratton really, really likes Rifampin for Cpni. He finds it one of the more potent anti-chlamydials although not for the faint of heart or those with higher initial load.  It specifically interferes with an enzyme that is required for the conversion of EBi's to RB's, and so gets them in this transitional phase. For this reason, I'd continue with at least one of the protease inhibitors (doxyi or azith) to cover those which have managed to become RB's to prevent their replication. 

With the monitoring you have I shouldn't see a problem taking it, particularly at this point. I would hold on the INH until you see your response to the Rifampin, and if it were me I would work to continuous flagyli first before adding the INH. Just because of the added liver focus. On the other hand, the combo of Rifampin and INH has been used long-term in the treatment of TB without significant problems for many. So it's not unheard of. Likely, at that point, you'd not need the doxy/azith along with it. But here is a better source of answers: have your doctor contact Dr. Stratton and get his expert recommendations. We are all guessing here based on our "educated consumer" view.  

CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 300mg INH, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Taking a break from continuous protocol)

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Rif is one of the cidalest

Rif is one of the cidalest of em all when it comes to non-growing M tb, which are quite tolerant of most agents.

Anyway, suppose doxyi is merely bacteriostatic to Varmint A, even at the highest possible clinical concentrations. That's an in vitro determination. In vivo, Varmint A may be constantly facing reactive oxygen species, etc. It may be unable to survive such assaults very long when its ribosomes are restrained by the "bacteriostatic" concentration of doxy; thus it may die.

I'm not sure there is much actual data to support that scenario. There hasn't been a heck of a lot of research on interaction between antibacterial drugs and antibacterial immunei effectors. Here's a very interesting and high-quality paper:

http://medicine.ucsd.edu/nizetlab/PublicationsPage/Bacteriostatics.pdf<

suggesting that bacteriostatic drugs may significantly interfere with certain antibacterial immune effectors. But obviously, in cases like ours, insofar as they may be more or less infectious, those immune effectors aren't doing so great on their own - else we wouldn't have got sick in the first place.

Rifampin inhibits the

Rifampin inhibits the synthesis of RNA, which is a bacteriostatic sort of way of working. But it certainly felt bacteriocidal to me, when I was taking it; and in any case the distinction isn't an absolute one; all these 'bacteriostatic' antibioticsi can kill bacteria, especially at high doses.

As for trying both at once, as Rica says, since this is all experimental stuff, it's probably best to add one at a time. I found rifampin to seriously increase the effect of pulses even without adding any INH.

Norman      It will be

Norman     

It will be interesting to see how my next pulse goes.  All pulses thus far have been relative cake walks.  I had 1 day during pulse 14 that I felt abysmal but I think it may have been due to other things than the pulse.

I'm planning on starting with Rifampin tomorrow.  I may add INHi in 3.5 weeks and haven't yet decided. 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Ok, I'll bite! I should

Ok, I'll bite! I should know the answer but can't quite find it; Why can't you begin with ONE of these imstead of two? Personally, with my circumstances, it would be Rifampin - it is familiar. You may have great improvement and if you take both, you won't have any idea why. I don't know the bug-resistance problems of INHi, so on the other hnd, maybe you should begin with that if there are not as many problems if you want to try them in tandem instead of concurrently. This may have been discussed before and somehow I missed it but this is a big decision I think it is a good one myself - exactly what the people here have been doing. Based on the information gathered so far, you know that you could probably go faster and this is the place to get any answers there may be. It there aren't any answers, well - find them!. My apologies for incoherence may be in order.

 

Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 44 pulses NC USA

3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Rica, no apologies

Rica, no apologies necessary, I followed the message quite well.  As you suggest, I've already decided to start the Rifampin first and later add the INHi.  I haven't yet decided as to whether or not I'll add it with my next pulse. 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Since I don't seem to have

Since I don't seem to have made myself clear: this isn't a road you have to go down. There's another road, labeled "continuous Flagyl", which leads in the same general direction. Since rifampin is better known for messing with the liver, it might be best to choose the other route, which is to move from pulsed metronidazolei to taking it continuously. That's certainly my plan at the moment, having tried rifampin and having been set back months by high liver enzymes: next time I'll try the other way.

By the way, INHi is also known for its chemical toxicity to the liver. (If memory serves, it produces free radicals there.)

There's a fair chance that most of the liver damage from these things is due to killing Cpni infecting the liver. My impression, John, is that you have a lower body burden of Cpn outside the brain than I do; so you might sail through this with no liver problems, even while taking medicines that mess with the liver via direct chemical effect. But then again, you might not. And doctors have a tendency, when liver enzymes rise, to take you off everything (which means letting the disease run free).

Thanks Norman for the

Thanks Norman for the reality check.  Yeah, maybe I don't _have_ to go down this road but it seems like it's about the best alternative available to me.  I've been on doxyi/azi for 15 months and have been on 2400 mg of NACi for about 6 months, so I'm thinking that the load is much smaller in my case.  The bulki of where I think the problem is would be the CNSi.  I'm not convinced of the efficacy of azi in penetrating the blood brain barrier but the efficacy of Rifampicin is established.  At the same time, I'm still taking it because the rest of the body will benefit from it's effects.

Now, as to continuous flagyl, that's an option, certainly.  I've been pulsing and am pulsing as we speak.  I'm on pulse 15.  What I don't know is how much good pulsing is doing, how much good anything is doing.  My progress has been woefully slow, though it's definitely there.  Continuous flagyl is certainly an option, as it a greater dose of all the bacteriostatics I've been on.

Now, correct me if I'm wrong, but isn't Rifampicin a bacteriocide rather than a bacteriostic?  I thought I read something about that somewhere but can't dredge up where to validate that notion.  As a bacteriocide, I would think it would have much more efficacy than a macrolide anyway.

Ok, so I haven't taken Rifampicin or INHi...yet.  Is it the consensus of the group that I shouldn't take either?  I'm planning on 150 mg of Rifampicin and 300 mg of INH (pulsed with flagyl) beginning next Saturday. 

Please let me know what your thoughts are if you haven't already.  Thanks.

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (nac, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Yes, NACi will help with

Yes, NACi will help with the liver.

John, I am only mentioning

John, I am only mentioning the sheet that the pharmacist always gives with any drug. With Rifampin it (as with some other abxi) says not to eat 2 hours before and some time after and, of course, the usual water. Nothing more. Hope you are running in circles soon!

 

Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 44 pulses NC USA

3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Rica Until you had mentioned

Rica

Until you had mentioned this, no pharmacist ever has given me any sheet with any drug I've ever been prescribed, ever.  I asked the pharmacist for an information sheet on Rifampin and INH when I got thos prescriptions filled.  What I got was this tiny, rolled-up thing that was taped to the dosage cards.  I haven't read them yet, but will be.

Now don't get all excited about my not having read this handouts.  I haven't started Rifampin or INH yet.  I've decided to wait on the INH, obviously.  It's supposed to be pulsed with flagyl, so I would take it yet anyway.

The Rifampin, I'm planning on beginning tomorrow, Saturday, so I will be reading that information sheet very soon, most definitely. 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Thanks for the comments

Thanks for the comments everyone, I really appreciate the time you're taking to talk this over with me though sometimes I might come across as a little less than grateful.  I am grateful, truly.

One thing that has crossed my mind about adding Rifampicin and INHi to the list of antibioticsi is that I'll be on a lot of things.  I'm not planning on discontinuing azithromycin or doxycycline with the addition of Rifampicin.  Should I be?

Same thing with INH...although I've read that it should be pulsed with Flagyl, so I don't believe there's any problem there.  Talk about pioneering though...I'm a little scared about this whole thing.

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Everything John? Don't

Everything John? Don't worry, you won't suddenly look as though you have a fake, bottle tan: after six months and a hot summer, I still looked as pale and interesting as ever!  However, urine is a different matter, even if you drink a lot of water.
  
Actually, apart from feeling the lack of immunomodulation when I started it in place of doxycycline, I felt nothing different.  I had already stopped getting much in the way of reactions to abxi by then, though: I must have already been in the phase of mending the damage caused by MSi rather than by the infection which caused the MS in the first place............Sarah  
  
An Itinerary in Light and Shadow  
Stratton/Wheldon regime since August 2003, for aggressive secondary progressive MS.  Intermittent therapy after one year. 2007 still take this two weeks every three months. Still slowly improving with no exacerbation since starting. EDSSi was 7, now 2
Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Sarah, thanks, that's just

Sarah, thanks, that's just how my doctor put it.."everything", so I wasn't sure just what that meant.  I was leaning towards all bodily fluids though, even tears and nasal drip. 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

I was about to disagree

I was about to disagree with Jim K, until I realized that by "die-like effect" he probably meant "dye-like effect", not dieoff effect. The color one gets in urine when taking the stuff (if one takes it correctly) is about the same as the color of the pills themselves.

As for rifampin and the liver, rifampin differs from most of the other antibioticsi used for Cpni in that it is absolutely known to mess with the liver simply by chemical action: it speeds up Phase 1 detoxification. With other antibiotics it could be that their liver effects are due mainly to killing Cpn infecting the liver, not to chemical action; but with rifampin, there's a lot of chemical action. (Speeding up detoxification may sound like a good thing, but speeding up just Phase 1 of it throws the system out of balance: the results of Phase 1, which themselves are toxins, can accumulate and poison the liver.) In one of Jim K's posts, he stated that it's Stratton's practice to reserve rifampin for after one has become comfortable with continuous metronidazolei; and rifampin's liver effects seem like a good reason for that practice. It's a good idea to put bacteria under as many different types of stresses as possible, but it's not a good idea to do the same to your liver. I was taking rifampin for a while, but had to stop due to elevations of liver enzymes; now that I'm restarting antibiotics, I plan to build up to continuous metronidazole, and only when comfortable with that to resume rifampin.

Norman       Thanks

Norman      

Thanks for the info though I don't know how I can put it to use.  I guess it's more of a little background information which is always good to have. 

As I mentioned to Jim, my doc and I are going to do monthly liver testing.  I really don't want to mess up my odds of making this happen, it is about the only shot I have at returning to a more "normal" function than I'm at now. 

Also, I posed a question about NAC to Jim in my earlier reply to hm and would ask you the same thing.  Will/can/does NAC mitigate the impact these drugs have on the liver?  Thanks. 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (nac, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Duly noted and edited!

Duly noted and edited! Thanks Norman. 

CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 300mg INHi, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Taking a break from continuous protocol)

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Let me emphasize Rica's

Let me emphasize Rica's concern about liver tests. Both Rifampin and INHi separately can affect liver enzymes, so I'd suggest monthly checks. Rifampin does turn things orange, but it's more a dye-like effect. The main thing about Rifampin is you need to stay with it for a number of months minimum so as not to generate resistant organisms, although this may be less of a concern with the other abxi on the protocol. I tried it for a while and didn't tolerate it well, so I'm interested in your coming experience.

I have upped my INH and I can say that it caused increased joint pains, very familiar to me from first year of pulses, suggesting that it was getting to bacteria the standard doxyi/azith was not. After so long on the protocol, to have 3 weeks of renewed pain of this nature from simply upping to full dose INH was a bit of a surprise. The mysteries of tissue penetration and MIB's and such continue to amaze me.

CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 300mg INH, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Taking a break from continuous protocol)

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Jim, see my comments to

Jim, see my comments to Rica.  I'm not real sure what instructions she's talking about, maybe you can clue me in.

As for liver testing, my doc and I are already going to do that monthly.  I think with everything I'll be taking, this isn't the time to tread lightly with the liver.  I'm not going down this road without some trepidation, I'm definitely apprehensive about it but by the same token it's  one of those things that has the potential to help me get out of the pit of MSi.  As such, it's a road I have to go down because the doxyi/azi combination isn't doing much. 

At the rate of improvement I'm seeing, I should be back to normal on that regime in about 20 years, just in time for retirement.  There's got to be an alternative I can try and this looks about like the only alternative.  Do you have any other suggestions on that?

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

I must caution you to have

I must caution you to have liver tests every 1 to 3 months. (I don't renenber which interval my doctor insisted on) Also, With Rifampin please read the instructions carefully and heed them. I began on Sept 4, 2004 with Rifampin and Doxyi and believe it was my brain fog at the time but it hit me really hard from the beginning. At the end of 16 months I could take it without noticable reaction but still made certain I went the full time required before and after taking it so that I could always get full benefit. I am looking forward to your experience with it because I hope to do a heavy program this late fall - possibly Rifampin, Doxy, Azithromycin and the closest I can come to continuous flagyli.

 

Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxy 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyl total 44 pulses NC USA

3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Rica, you've suggested this

Rica, you've suggested this in the past and I'm confused as to which instructions to which you are referring.  Are you talking about the instructions printed on the bottle from the pharmacy or something else?  I have no other documentation so I'm at a loss to understand what instructions you mean.

However, rest assured, I'm not taking this up lightly.  I know that both Rifampicin and INHi on their own are not things to toy with.  Given that I'm already on Doxyi, Azithro, and Flagyl, we're playing some hard ball here, no doubt.

I wonder though whether or not the 2400 mg of NACi I take each day will help to mitigate the liver effects? 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (nac, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day