Stratton/Mitchell & Siram Case Reports

Does it work?

It has been noted that most users of the combination antibiotic protocolsi commenting here have not been on the treatment long enough to give a big enough pool of reports to feel assured of the efficacy of this approach. I had asked Drs. Stratton, Wheldon, and Powell to perhaps tally up at least some basic numbers from their case experience to help us out with this problem, but this would involve problems of confidentiality and use of private data, etc.  

Then, I suddenly realized that we already have a good list of anecdotal reports of response to treatment reported data available to us... right in the Stratton/Mitchell patent materials! (Sheepish, embarrassed grin). So I took it as a project to summarize this data by disease treated. Occasionally I have used the exact wording from the patent materials as they were brief and descriptive. We have the full text referenced in our treatment and links if you want to see more detail.

All reported had with positive serologyi for Cpni using the highly sensitive tests developed by Stratton/Mitchell. I left out a few whose diagnosis was not clear to me, you can see them in the patent materials #6,884,784
All on some form of the combination antibiotic therapy protocol.

MS

  1. EDSSi score 8.0- Treatment nine month- EDSS 3.0
  2. EDSS score 8.0 Treatment six months- EDSS 6.5
  3. EDSS score 7.5.  Treatment five months- EDSS 6.5.
  4. EDSS score 8.5  Treatment six months- no further progression of symptoms
  5. 10 years wheel chair  bound  Treatment six months- stands unaided, several steps, dec fatigue and cognitive dysfunction.
  6. Long hx MS with 2-3 year progression   Treatment fourteen months- improved incontinence, stamina, speech. Continues to be wheel chair bound.
  7. One year MS, foot drop, walks with cane.   Treatment four months- no longer requires cane.
  8. One year MS. Cane, rolling gait, fatigue.   Treatment twelve months- no cane, no fatigue on walking

 

RA

Treatment two months. Complete remission of RA symptoms.

IC

Treatment two months. Complete remission of symptoms. Stopped tx, return of IC symptoms.

IBD

  1. Treatment six months. No further evidence of IBD. Bowel habits normal, no steroids, cognitive dysfunction and depression resolved.
  2. Treatment six months. No further evidence of IBD. Neurologic, fatigue, myalias, athralgias, rash resolved.
  3. Six year history of inflammatory bowel diseasei (uncertain CD or UC) associated with painless rectal bleeding, arthritis, myalgias, skin ulceration, abdominal cramping/diarrhea, and rectal fistulas. She had increasing fatigue. Symptom free (after going off abxi on vacation and relapsing) after one year of treatment. On combination antibiotics her ileostomy activity was more regular and less spastic. She claimed to feel better with higher energy levels and ceased antibiotic therapy. Six months post- antibiotic therapy she remained asymptomatic other than a moderate anemia.
  4. On combination antibiotics she experience some symptomatic improvement but failed to completely resolve her IBD symptoms. She discontinued antibiotics due to a probable chronic Herxheimer reaction. Currently she is lost to follow-up.
  5. Colitis with inflamed distal sigmoid colon and proctitis associated with frequent loose stools with significant mucus. Following six weeks of combination antibiotic therapy with a significant reduction in symptoms. Shortly after cessation of antibiotics her symptoms return. Reinstitution of antibiotics resulted in a second remission of the majority of her symptoms with resolution of her proctitis on visual exam.

 

CFSi<

  1. Insidious onset of debilitating fatigue. This was associated with a severe cognitive dysfunction that disrupted his ability to function. Combination antibiotics with complete reversal of symptoms after six months. He remains asymptomatic.
  2. 10 year history of CFS with severe cognition problems. Herxheimer reaction with resolution over two week period on treatment. He remains on combination antibiotics for over ayear and is asymptomatic.
  3. Physician with long-standing CFS. Treated with combination antibiotics with gradual resolution of symptoms. During course of treatment developed cardiac myopathy. Currently asymptomatic from CFS. Cardiac myopathy resolved over six month period on combination antibiotics.
  4. Five year history of severe CFS with debilitating cognitive dysfunction and depression. Gradual improvement on combination antibiotics for approximately nine months. Estimated 75% of normal function.
  5. Ten year history CFS with cognitive dysfunction. Complete response to combination antibiotics over a course of one year.
  6. Moderate fatigue and cognitive dysfunction following acute infectious illness. Depression was major problem. During one year course of combination antibiotics fatigue and cognitive dysfunction largely reversed. During mid-course of therapy patient developed acute anxiety attacks relieved by anti-porphyrin therapy.
  7. Fatigue following acute stress. On combination antibiotic therapy at 3 months became asymptomatic. Cessation of antibiotics resulted in symptomatic relapses. Currently asymptomatic with low serum antibodies and negative PCRi.
  8. Short history of CF and cognitive dysfunction affecting studies. Combination antibiotics over a multi-month course resulted in complete reversal of symptoms.
  9. Three year history of CFS with FM. Combination antibiotic therapy has resulted in partial reversal of symptoms allowing her to retain a job in jeopardy. Estimated 80-90% normal function currently.
  10. History of fatigue although non-incapacitating. Combination antibiotic therapy has resulted in 100% return to normal function.
  11. Teen-ager with long history of CFS resulting in home-bound schooling. On combination antibiotic therapy returned to school and recently graduated. Recovery has not been complete probably secondary to non-compliance in therapy.



FM

Three year history of debilitating FM following the stress of being a stalking
victim. Patient relatively asymptomatic after nine months combination
antibiotic therapy.

Siram's cases

You will find followup reports from Dr. Siram's cases by a man who actually tracked down personally those he could find. These are all MS cases, and all report improvement, some quite spectacular, such as the wheelchair bound tri-pelegic former cop who was able to resume his former job! But please note: some people used flagyli, and other antibiotics only. The inconsistencies of degree of improvement seems mostly due to this factor in my read. Remember that this was in 1994 when the understanding of the importance of the whole protocol, especially the critical importance of flagyl, was still evolving. Click here for link.<

Comments

Jim, thank you for your hard, valuable work on making these results available here. I use this site all the time!

On Stratton protocol for CFSi starting 01/06.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

Thank you for taking the time to complie this Jim! Chris CAPi since 11/06 for CFSi. Cpni, Myco P, CMV, HHV-6 infectionsi. Zithi 500 mg Tues, Thurs/Doxyi 200mg MWF. All supplementsi.
CAPi since 11/06 for Cpni, Lyme, Bartonella, Babesia, Myco P, CMV, HHV-6 infectionsi. Rifampin 600mg daily, Zithromax 500mg daily. NACi 2250mg daily. All other supplementsi. Now Bicillin LA 2.4 mil injection weekly.

Thanks, was actually written a year ago, nice to re-read it. It's worth noting when you see the short time span of treatment that the CAPi used here was continuous antibioticsi, including the flagyli<, not pulses. Probably slammed them worse (hence some of the stop and start of treatment for some) but appeared to make for shorter course of treatment. How they did it I have no idea, as it's taken me two years to get to the point that I can even conceive of doing continuous treatment.

CAP for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 150mg INHi, 300mg Rifampin, 200 Doxycycline, 500mg mwf Azithromycin, plus 500mg Tinidazole 2x/day pulses every two weeks. Whew! That's a lot!

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Jim, found a broken link.  It's the link to Dr. Siram's cases in the handbook.  If you can find the page, would love to see it.

all my best

John

 

p.s.:  is it Siram or Sriam??

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

 I'm afraid this isn't a broken link but rather that his pages no longer exist, or at least not on Earthlink. If anyone finds where they have gone, let me know.

CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 150mg INHi, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Continuous protocol)

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

And I thought it was SRIRAM, John, so maybe someone can clear it up.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Jim, I took the link above and used the WayBackMachine found at www.archive.org< to find the pages and read some of them.  Interestingly, you might look at the antibioticsi page and the information about BBBi penetration of anti Cpni antibiotics.  For people with MSi, it looks from this source like Azithromycin is probably not a good choice.  Obviously, more data about it is needed.  Here is a link to the WayBackMachine that has the pages/site archived: http://web.archive.org/web/*/http://home.earthlink.net/~robert016/mss.htm< 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

It is Sriram. The way back machine is really cool! I used to keep that link in my favorites and was sad it was gone so having it still available is good. Those original case studies are interesting marie On CAPi since Sept '05 for MSi, RA, Asthmai, sciatica. EDSSi at start 5.5. Currently on: Doxyi 200, Azith 3x week, Tinii cont. since April '07, all supplementsi. "Color out side the lines!"

On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

Logging on to track this post.

Also I am looking forward to examining this link to the link that Jim mentioned provided by John in his older ost above;   http://web.archive.org/web/*/http://home.earthlink.net/~robert016/mss.htm<

This link to the web archive is a new one for me.

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <
And, you can add my 98% or so improvement of MSi in my three years on abxi. Thanks for posting this, Jim.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

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