Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production

Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production< HD Danenberg, G Alpert, S Lustig and D Ben-Nathan Department of Virology, Israel Institute for Biological Research, Ness- Ziona.

Recent reports have demonstrated an immunomodulating activity of dehydroepiandrosterone (DHEAi) different from that described for glucocorticoids. The present study was designed to test DHEA's activity in endotoxic shock and to investigate its effect on endotoxin-induced production of tumor necrosis factor (TNF). Mortality of CD-1 mice exposed to a lethal dose of lipopolysaccharidei (LPSi; 800 micrograms per mouse) was reduced from 95 to 24% by treatment with a single dose of DHEA, given 5 min before LPS. LPS administration resulted in high levels of TNF, a response that was significantly blocked by DHEA, both in vivo and in vitro. DHEA treatment also reduced LPS-induced increments in serum corticosterone levels, a parameter considered not to be mediated by TNF. In another experimental model, mice sensitized with D-galactosamine, followed by administration of recombinant human TNF, were subjected to 89% mortality rate, which was reduced to 55% in DHEA-treated mice. These data show that DHEA protects mice from endotoxin lethality. The protective effect is probably mediated by reduction of TNF production as well as by effecting both TNF-induced and non-TNF-induced phenomena.

http://www.endotoxin.gmxhome.de/artikel3.html This one's an interesting story about a woman who was exposed to a much more lethal LPS than CPn,s is. She used DHEA to ameliorate it.

Comments

This is good to know. Both links go to the same study though.

Link corrected. Thanks for finding the error. 

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

LPSi and DHEAi<

I am the woman, who was contaminated with LPS from Salmonella minnesota and I have made good experience with the treatment of DHEA. I have another website about the efficacy of DHEA in the treatment of LPS-induced Parkinson's Disease:

http://www.endotoxin.gmxhome.de/dhea.html<

Ines

Ines, thank you for commenting on this. How much DHEAi do you take and how often? Do you notice a significant difference?

Raven 

Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath

Ines hello! I read your paper some time ago I have it as a favorite! Greetings!
Jim this is an important paper as many studies indicate that DHEAi reduces EAE in mice also, so we have another smoking gun that probably has more to do with the impact of immunity on the CNSi than it has to do with hormones causing MSi.

In other words, the hormone connection to MS has more to do with the fact that hormones influence immunity and thus reaction to things like LPSi...not an autoimmune issue or simple "hormone imbalance" that just went too far in a genetically susceptible person

I wonder if DHEA might be effective as a infammation repressor for CAPi treatment protocols-I think I may have written DW about this and asked that question some time ago and do not remember the answer, but it is a good idea and I formed it based on Ines paper.
Blessing to you Ines!
marie

On CAP since Sept '05 for MS, RAi, Asthmai, sciatica. EDSSi at start5.5.
"Color out side the lines!"

On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

I seem to remember thinking that DHEAi shouldn't be taken with certain abxi (maybe flagyli and tinii?) because of p450 pathway interactions.

- Kate D

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