David Wheldon comments on Relapses and Pseudo-relapses In Treating Cpn in Multiple Sclerosis (MS)

(Comment from David Wheldoni's site http://www.davidwheldon.co.uk/relapse_pseudo.html)

The relapse in early relapsing-remitting MSi has a typical pathology irrespective of its location. The first visible event is the orderly, local, mass death of oligodendrocyctes, the cells which support myelini. The myelin associated with these cells then degenerates. Degenerating myelin activates an inflammatory process. When this is over, young oligodendrocytes mature and make new myelin. The clinical counterpart to this pathology (unless it occurs in a silent area) is a loss of function which worsens over several hours to two days. The loss of function remains in place until the inflammation is over and remyelinationi begins. It will thus be seen that the relapse has a definite pattern and timescale.

Some people experience strange new sensations on beginning antibiotics and are often afraid that these are relapses. While relapses can occur during the first few months of antibiotics, probably initiated by virus infections, these sensations do not fulfil the timescale criteria of true relapses and tend to change their form within a week. Sometimes, in fact, they herald a return of function. What causes these 'pseudo-relapses' I do not know, but I suspect it is rebudding of neurones which make trial-and-error connections. Synaesthesia (crossover of the senses) can sometimes result; as an example, the seeing of flashes of light when hearing a loud noise. They can be quite troubling even when improvement is taking place. Repair takes place at a cellular level; function has to be re-learned at a much higher level.

Comments

David is one of the few people with clinical experience treating patients with MSi for Cpni. These clinical observations on pseudo relapse and his thoughts about might be it's nature will help those with MS better discern what's a general "herx" from what is specific in the treatment of their particular disease with Cpn treatment.

On Wheldon protocol for CFSi/FMSi since December 2004.

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

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