Detection of chlamydial bodies and antigens in the central nervous

J Infect Dis. 2005 Oct 1;192(7):1219-28. Epub 2005 Sep 2. Related

Detection of chlamydial bodies and antigens in the central nervous
system of patients with multiple sclerosis.

Sriram S, Ljunggren-Rose A, Yao SY, Whetsell WO Jr.

Department of Neurology, Vanderbilt University Medical Center,
Nashville, Tennessee, USA. subramaniam.sriram@vanderbilt.edu.

To examine a possible relationship between Chlamydia pneumoniae
infection and multiple sclerosis (MSi), we undertook an
immunohistochemical (IHC), molecular, and ultrastructural comparison
of central nervous system (CNSi) tissue and cerebrospinal fluid (CSF)
sediment from patients with MS and control individuals with other
neurological diseases (ONDs). In 7 of 20 MS cases, IHC staining was
seen in association with ependymal surfaces and periventricular
regions of formalin-fixed brain tissue, by use of 3 different
antichlamydial antibodies. There was no staining with any of the 3
antichlamydial antibodies in formalin-fixed brain tissue from OND
controls (n=17). With available frozen CNS tissue, polymerase chain
reaction (PCRi) studies for the presence of C. pneumoniae genesi were
performed. The presence of a PCR signal was confirmed in 5 of 8 MS
cases and in 3 of 18 OND controls. In an examination of CSF sediment
by electron microscopy, we observed electron-dense structures
resembling chlamydial organisms in CSF sediments from 11 of 20 MS
cases and 2 of 12 OND controls. The presence of immunogold-labeled
electron-dense bodies was correlated with the presence of a PCR
signal in 10 of 11 MS cases. Results of studies using these different
approaches support our suspicion of the presence of chlamydial
organisms in the CNS, in a subset of patients with MS.

PMID: 16136465 [PubMed - in process]

Comments

This is all very exciting, thank you for the information.  Makes my neurologist look a little silly as she flatly dismissed bacterial components in MSi.

 

With Christ in Faith

Ruth 

CFIDSi/ME, FMSi, MCS, IBSi, EBVi, CMV, Cpni, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplementsi+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyli/day-5 days<

Ruth this is a very old page created when we created the research pages for the site: about two weeks after it started! We have a lot of research in the research pages on just these issues. I add things, especially good finds by other members that fit our mission statement, regularly. By all means do read as much of it as you can, and go ahead and read the physicians pages too, they are meant for all of us not just the docs.
marie
On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5. Currently on: Doxy 200, Azith 3x week, Tini cont. since April '07, all supplementsi.
"Color out side the lines!"

On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

Thanks Marie,

I read what I can & absorb as much as possible.  But alas, the science terminology is somewhat lost on me, but give me time; I may get the hang of the MD speak.Laughing  I skim read that stuff & look for the bottom line at the end in the summary!  Thanks for all you work as one of the "founding members" on the site.

Blessings,

With Christ in Faith

Ruth 

CFIDSi/ME, FMSi, MCS, IBSi, EBVi, CMV, Cpni, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplementsi+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyli/day-5 days<

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