Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae

This paper was authored by Stratton and Wheldon the two doctors whose protocols and comments appear on this site. Here is the abstract as the copyright to the whole citation belongs to the magazine.

Trends Microbiol. 2006 Sep 21;
Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae.

Stratton CW, Wheldon DB.

Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

The concept of autoimmune myelinopathy as the primary pathology in multiple sclerosis (MSi) is problematic. Vasculitisi is seen in the MS brain, both within lesions and in adjacent normal-appearing white matter. The first observation in acute relapse is the sudden, orderly death of oligodendrocytes; inflammatory removal of unsupported myelini seems to be a secondary process. An alternative explanation for these findings is that oligodendrocytei infection might trigger an inflammatory response. Many pathogens, including Chlamydophila (Chlamydia) pneumoniae, have been associated with MS. MS might be an infectious syndrome in which C. pneumoniae has a role in a subset of patients. Mechanisms by which such a cryptic infection could engender relapsing-remitting and, ultimately, progressive disease patterns are discussed.
PMID: 16996738 [PubMed - as supplied by publisher]

Key to this paper is the careful and well supported progression of ideas which makes the possibility of CPn as cause for MS become understandable. Here is a taste of what is available in the whole citation:
"C. pneumoniae has been shown to infect human brain microvascular endothelial cells in vitro resulting in alteration of the junctional complex proteins.[40] This alteration, in turn, promotes the transmigration of monocytes through these C. pneumoniae infected endothelial cells.[41] In this manner, infection at the level of the CNSi vasculature may be a key initiating factor in the pathogenesis of neurodegenerative diseases.[40-42]" end quote

Once one understand how CPn works in the human body, it becomes obvious that the CNS could be infected and should this happen, just as is so in other parts of the body, failure of the body to clear the organism is possible and the cascade of inflammatory events would occur and be at least similar to MS, an inflammatory illness of the CNS of unknown etiology. This paper is worth tracking down and reading for the potentially prescribing physician as it presents the model clearly and thoroughly.