28th pulse (first tini)

A few days ago I finished pulse which was also the first tinii pulse. It was a big difference comparing to metroi. Though last metropulses did for me just little reactions now I almost didn't know I was pulsing. Even I took tini and immediately after that I was thinking wether I took it or not. I had to count the pills just to confirm I took it. After metro I always knew I had taken it because my stomack could feel it -  sometime more, sometime less but I always knew I had taken it. Also I didn't have any other reactions during the pulse and also after the pulse so far. The only reaction so far is my legs are stronger. Not only the legs are stronger but also my hips are. Now my walking goes from my waist downwards. I use all muscles from waist to toes. It's really strange a healthy one can't realize where the walking comes from. Now when I walk I realize I use not only my legs but also my bottom and the balance in the hips is better. And I also can get better to the bathtubWink. My hips don't limit me so much. I think I can walk more but I will wait a little and then I will write if it's really so.

Comments

Tini vs. Metro

Hi Evita,

A possible explanation for the lower side effects seen by tinidazole vs. metronidazole might be the dosage. If one assumes that both of these agents act by lowering the intracellualr pH of C. Pneumonia, which seems likely at this point, then one might argue that these agents work in a dose and pH dependent way. Their pH (pKa) levels are very close with tini at 2.34 and metro at 2.5. These are close enough in pKa and similar enough molecules that it is possible that they have identical pKa's and the small difference might only be from accuracy in measurement. Since tinidazole is usually given in lower dosages, 400 mg vs 500 mg, one might expect that it lowers the pH of C. Pneumonia in less cells and thereby elicits less side effects.

Even if this is correct and seems to argue that tinidazole might be inferior to metronidazole, I do not think that is the case. It might mean that one would want to start with tinidazole and either increase the dosage or switch to metronidazole later in therapy. I do not believe it is possible to eliminate C. Pneuminia very quickly as the immunei reaction to this would probably be intolerable, even dangerous. So finding a way to build up slowly probably makes the most sense.

Also none of this is meant to disaparage either of these agents. Both in vitro and in vivo testing has tended to show they are the best ones available. And the way they are dosed seems to work and make sense. Essentially one kills as much as they can for a few days and then allows the immune system to down regulate for a few weeks before pulsing again. This seems to me to be about as elegant a way to attack this systemic infection as any.

Edit: After rereading this, I realized that I might be suggesting people might change their dosing of metro or tini. I really did not mean to do that as I do not even have anecdotal evidence with myself or others to back that up. It may or may not be a good idea but would fall on Dr. Stratton or Dr. Wheldon to make that determination. And since Dr. Stratton is not really involved in updating protocol suggestions, it would most likely be up to Dr. Wheldon to decide if this is a vaild course or not.

- Paul

Tini

I have had your same experience - I love tinii.  On day 2 of my pulse I feel great - legs, hips...all better.  I can walk and I have been in a wheelchair.  I only had 30 steps with a walker now I can sometimes make 300.  I still have a long way to go, I am trying to force myself to walk daily.  Only make it a half hour with rests.    I had done tons of metroi...with not that great of results as I felt awful.  I also need to give rocephini some credit!

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tinii pulses,100 mg diflucan, 4.5 ldni; Wheldon protocol for MSi April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

Wiggi I am happy to hear how

Wiggi I am happy to hear how tinii makes good for your walking. Yes, the walking is problem but I believe with the tini our walking will be improving with each pulse.

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi 

hi...

should i be replacing flagyli with tinii? and btw...what is tini? thanks in advance guy's!

You guys have sold me on it.

You guys have sold me on it. I already ordered mine Smile

Leetz- It's "Tinidazole" 

 

RRMSi, Dxi 1/2006, CAPi 6/2010. Currently: 200 mg Doxyi, 250 mg Azithro (MWF), 1 g Amoxi, 1 g Tinii (5 d pulse), 2400 mg NACi, 3.5 mg LDNi, 5 mg Pred., 10 g Vit D, 800 mg Vit E, 400 mg ALA, 800 mg ALC, 1 g LMM, D-Mannose

Steady on there, everyone! 

Steady on there, everyone!  Tinidazole is very similar to metronidazole (flagyl) but does seem to be easier to take.  For instance, a couple of people I know here, had hallucinations whilst taking metronidazole but not when they swapped to tinidazole.  All imidazoles can make anyone feel grotty when taking them, because of the medicine, not the pathogen, but out of thee, tinidazole tends to be easier to take, which if you are taking things for a long period is no bad thing.  I changed to tinidazole sometime after starting intermittent therapy and I don’t regret it.  Other people, such as Rica swear by flagyl.  It is now licensed in both the US and the UK, but many doctors prefer flagyl, partly because that is what they are used to and partly because it costs less, being out of patent.

I can’t say whether I had more improvement with tinidazole or metronidazole, but I could take tinidazole more easily.  The fact that you only take it twice a day and not three times helps!................... Sarah

A Journey through Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.